Nuclear Inositides and Inositide-Dependent Signaling Pathways in Myelodysplastic Syndromes

Author:

Xian Jie,Owusu Obeng Eric,Ratti StefanoORCID,Rusciano Isabella,Marvi Maria Vittoria,Fazio Antonietta,De Stefano Alessia,Mongiorgi Sara,Cappellini Alessandra,Ramazzotti GiuliaORCID,Manzoli Lucia,Cocco Lucio,Follo Matilde Yung

Abstract

Myelodysplastic syndromes (MDS) are a heterogeneous group of hematological malignancies characterized by peripheral blood cytopenia and abnormal myeloproliferation, as well as a variable risk of evolution into acute myeloid leukemia (AML). The nucleus is a highly organized organelle with several distinct domains where nuclear inositides localize to mediate essential cellular events. Nuclear inositides play a critical role in the modulation of erythropoiesis or myelopoiesis. Here, we briefly review the nuclear structure, the localization of inositides and their metabolic enzymes in subnuclear compartments, and the molecular aspects of nuclear inositides in MDS.

Funder

Fondazione del Monte di Bologna e Ravenna

China Scholarship Council

Publisher

MDPI AG

Subject

General Medicine

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