Affiliation:
1. Department of Cardiology, Fukuoka University School of Medicine, Fukuoka 814-0133, Japan
2. Department of Internal Medicine, Fukuoka University Nishijin Hospital, Fukuoka 814-0005, Japan
Abstract
The liver fibrosis score reflects the degree of hepatic scarring and has been reported to be associated with cardiovascular disease. Using a coronary artery computed tomography angiography registry at the Fukuoka University Hospital (FU-CCTA registry), we investigated the association between major adverse cardiovascular events (MACEs) and the liver fibrosis score (fibrosis-4 index (FIB-4I)) in 612 patients who underwent CCTA to screen for coronary artery disease and performed a prognosis survey for up to 5 years. The primary endpoint was MACEs (all-cause mortality, acute myocardial infarction, ischemic stroke, coronary revascularization). FIB-4I in all patients and in patients with hypertension (HTN) was significantly higher in the MACE group than in the non-MACE group. The event-free survival rate of MACEs targeting only patients with HTN was significantly lower in patients with a high risk of liver fibrosis (FIB-4I values of 2.67 or higher) than in those with a low or intermediate risk (less than 2.67). However, no significant difference was observed in all patients or in patients without HTN. Finally, FIB-4I and body mass index were independent factors associated with MACEs in patients with HTN. In conclusion, the liver fibrosis score may be an independent predictor of MACEs in hypertensive patients undergoing CCTA.
Reference34 articles.
1. Cardio-renal syndromes: Report from the consensus conference of the acute dialysis quality initiative;Ronco;Eur. Heart J.,2010
2. Cardiohepatic syndrome;Poelzl;Curr. Heart Fail. Rep.,2015
3. Cardiohepatic interactions in heart failure: An overview and clinical implications;Samsky;J. Am. Coll. Cardiol.,2013
4. Sato, S., Kawai, H., Sato, S., Iwasaki, H., Omori, M., Kita, Y., Ikeda, Y., Awatsu, T., Murata, A., and Taniguchi, G. (2022). Hypertension and diabetes mellitus are associated with high FIB-4 index in a health checkup examination cohort without known liver disease. BMC Gastroenterol., 22.
5. Fibrosis-4 Index Is Closely Associated with Arterial Damage and Future Risk of Coronary Heart Disease in Type 2 Diabetes;Watanabe;Int. J. Hypertens.,2022