Magnetic Resonance Volumetric Quantification of Vestibular Endolymphatic Hydrops in Patients with Unilateral Definite Meniere’s Disease Using 3D Inversion Recovery with Real Reconstruction (3D-REAL-IR) Sequence

Author:

Suárez-Vega Víctor1ORCID,Manrique-Huarte Raquel2ORCID,Dominguez Pablo3ORCID,Blanco Melissa4,Alonso-Burgos Alberto1,Pérez-Fernández Nicolás4ORCID

Affiliation:

1. Department of Radiology, Clinica Universidad de Navarra, 28027 Madrid, Spain

2. Department of Otorhinolaryngology, Clinica Universidad de Navarra, 31008 Pamplona, Spain

3. Department of Radiology, Clinica Universidad de Navarra, 31008 Pamplona, Spain

4. Department of Otorhinolaryngology, Clinica Universidad de Navarra, 28027 Madrid, Spain

Abstract

Background: The 3D-REAL-IR MRI sequence allows for an in vivo visualization of endolymphatic hydrops. Qualitative assessment methods of the severity of vestibular and cochlear hydrops are the most commonly used. Methods: A quantitative volumetric measurement of vestibular EH in patients with definite unilateral Ménière’s disease using the 3D-REAL-IR sequence and the calculation of the endolymphatic ratio (ELR) was intended. Results: Volumetric calculations of the vestibules, vestibular endolymph and vestibular ELR are performed in 96 patients with unilateral Ménière’s disease and correlated with classic qualitative grading scales. Conclusions: Quantitative volumetric measurement of vestibular hydrops using the 3D-REAL-IR sequence is feasible and reproducible in daily clinical practice. Vestibular ELR values exceeding 60% defined radiologically significant vestibular hydrops, while values below 30% defined radiologically non-significant vestibular hydrops.

Funder

ISCIII

ERDF, “A way to make Europe” Instituto de Salud Carlos III

Ministerio de Ciencia, Innovación y Universidades. Government of Spain

Resolution of the Directorate of the Carlos III Health Institute

European Regional Development Fund

Publisher

MDPI AG

Subject

General Medicine

Reference26 articles.

1. Current Epidemiology of Meniere’s Syndrome;Alexander;Otolaryngol. Clin. N. Am.,2010

2. What is Menière’s disease? A contemporary re-evaluation of endolymphatic hydrops;Zou;J. Neurol.,2016

3. The vestibulo-ocular reflex assessment in patients with Ménière’s disease: Examining all semicircular canals;Lujan;Acta Oto Laryngol.,2014

4. Pathologie auriculaire: Mémoire sur des lésions de l’oreille interne donnant lieu à des symptômes de congestion cérébrale apoplectiforme;Gaz. Médicale Paris,1861

5. Endolymphatic Hydrops: Pathophysiology and Experimental Models;Salt;Otolaryngol. Clin. N. Am.,2010

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