UV/H2O2-Degraded Polysaccharides from Sargassum fusiforme: Purification, Structural Properties, and Anti-Inflammatory Activity-Reference-Cited by-同舟云学术

UV/H2O2-Degraded Polysaccharides from Sargassum fusiforme: Purification, Structural Properties, and Anti-Inflammatory Activity

Published:2023-10-26 Issue:11 Volume:21 Page:561
ISSN:1660-3397
Container-title:Marine Drugs
language:en
Short-container-title:Marine Drugs

Author:

Chang Shiyuan¹,Chen Xiaoyong¹²,Chen Yifan¹,You Lijun¹³^ORCID,Hileuskaya Kseniya⁴

Affiliation:

1. School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China

2. College of Food Science, Southwest University, Chongqing 400715, China

3. Overseas Expertise Introduction Center for Food Nutrition and Human Health (111 Center), Guangzhou 510640, China

4. Institute of Chemistry of New Materials, National Academy of Sciences of Belarus, 36F. Skaryna Str., 220141 Minsk, Belarus

Abstract

The main purpose of this study was to analyze the structural properties and anti-inflammatory activity of the purified fractions derived from UV/H2O2-degraded polysaccharides from Sargassum fusiforme. Results indicated that twofractions with different monosaccharide compositions and morphological characteristics, PT-0.25 (yield 39.5%) and PT-0.5 (yield 23.9%), were obtained. The average molecular weights of PT-0.25 and PT-0.5 were 14.52 kDa and 22.89 kDa, respectively. In addition, PT-0.5 exhibited better anti-inflammatory activity with a clear dose dependence. The mechanism was associated with the inhibition of LPS-activated Toll-like receptor 4-mediated inflammatory pathways in RAW264.7 cells. The results showed that PT-0.5 was a complex polysaccharide mainly composed of 4-Fucp, t-Manp, 6-Galp, t-Fucp, and 3,4-GlcAp. These results would provide theoretical support for studying the structural properties and biological activities of UV/H2O2-degraded polysaccharides.

Funder

National Natural Science Foundation of China

Excellent Youth Foundation of Guangdong Scientific Committee

Guangdong Basic and Applied Basic Research Foundation

Guangdong Science and Technology Plan Projects

Natural Science Foundation of Chongqing

111 Project

Publisher

MDPI AG

Subject

Drug Discovery,Pharmacology, Toxicology and Pharmaceutics (miscellaneous),Pharmaceutical Science

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