Machine Learning Based Extraction of Boundary Conditions from Doppler Echo Images for Patient Specific Coarctation of the Aorta: Computational Fluid Dynamics Study

Abstract

Patient-specific computational fluid dynamics (CFD) studies on coarctation of the aorta (CoA) in resource-constrained settings are limited by the available imaging modalities for geometry and velocity data acquisition. Doppler echocardiography is considered a suitable velocity acquisition modality due to its low cost and safety. This study aims to investigate the application of classical machine learning (ML) methods to create an adequate and robust approach to obtain boundary conditions (BCs) from Doppler echocardiography images for haemodynamic modelling using CFD. Our proposed approach combines ML and CFD to model haemodynamic flow within the region of interest. The key feature of the approach is the use of ML models to calibrate the inlet and outlet BCs of the CFD model. In the ML model, patient heart rate served as the crucial input variable due to its temporal variation across the measured vessels. ANSYS Fluent was used for the CFD component of the study, whilst the Scikit-learn Python library was used for the ML component. We validated our approach against a real clinical case of severe CoA before intervention. The maximum coarctation velocity of our simulations was compared to the measured maximum coarctation velocity obtained from the patient whose geometry was used within the study. Of the 5 mL models used to obtain BCs, the top model was within 5% of the maximum measured coarctation velocity. The framework demonstrated that it was capable of taking into account variations in the patient’s heart rate between measurements. Therefore, it allowed for the calculation of BCs that were physiologically realistic when the measurements across each vessel were scaled to the same heart rate while providing a reasonably accurate solution.