New Research on the Bacillus anthracis Genetic Diversity in Siberia
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Published:2023-10-18
Issue:10
Volume:12
Page:1257
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ISSN:2076-0817
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Container-title:Pathogens
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language:en
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Short-container-title:Pathogens
Author:
Timofeev Vitalii1ORCID, Bakhteeva Irina1ORCID, Khlopova Kseniya1, Mironova Raisa1, Titareva Galina1, Goncharova Yulia1, Solomentsev Viktor1, Kravchenko Tatiana1, Dyatlov Ivan1, Vergnaud Gilles2ORCID
Affiliation:
1. State Research Center for Applied Microbiology and Biotechnology (SRCAMB), 142279 Obolensk, Russia 2. Institute for Integrative Biology of the Cell (I2BC), Université Paris-Saclay, CEA, CNRS, 91198 Gif-sur-Yvette, France
Abstract
Anthrax is a particularly dangerous infection of humans and ungulates caused by the Gram-positive spore-forming bacterium Bacillus anthracis. The highly monomorphic and clonal species B. anthracis is commonly divided into three main lineages, A, B, and C, which in turn are divided into several canSNP groups. We report here a phylogenetic analysis based on the whole-genome sequence (WGS) data of fifteen strains isolated predominantly in Siberia or Central and Southern Russia. We confirm the wide distribution of the cluster of strains of the B.Br.001/002 group, endemic to the Russian Arctic, which is also present in the steppe zone of Southern Siberia. We characterize additional branches within the major A.Br.001/002 polytomy comprising the A.Br.Ames and A.Br.Sterne lineages, one of which is identified in the Arctic.
Funder
Sectoral Scientific Program of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
Subject
Infectious Diseases,Microbiology (medical),General Immunology and Microbiology,Molecular Biology,Immunology and Allergy
Reference33 articles.
1. Jiranantasak, T., Benn, J.S., Metrailer, M.C., Sawyer, S.J., Burns, M.Q., Bluhm, A.P., Blackburn, J.K., and Norris, M.H. (2022). Characterization of Bacillus anthracis replication and persistence on environmental substrates associated with wildlife anthrax outbreaks. PLoS ONE, 17. 2. Hsieh, H.Y., and Stewart, G.C. (2023). Does environmental replication contribute to Bacillus anthracis spore persistence and infectivity in soil?. Res. Microbiol., 174. 3. Timofeev, V., Bahtejeva, I., Mironova, R., Titareva, G., Lev, I., Christiany, D., Borzilov, A., Bogun, A., and Vergnaud, G. (2019). Insights from Bacillus anthracis strains isolated from permafrost in the tundra zone of Russia. PLoS ONE, 14. 4. Kenefic, L.J., Pearson, T., Okinaka, R.T., Schupp, J.M., Wagner, D.M., Hoffmaster, A.R., Trim, C.B., Chung, W.K., Beaudry, J.A., and Jiang, L. (2009). Pre-Columbian origins for North American anthrax. PLoS ONE, 4. 5. Van Ert, M.N., Easterday, W.R., Huynh, L.Y., Okinaka, R.T., Hugh-Jones, M.E., Ravel, J., Zanecki, S.R., Pearson, T., Simonson, T.S., and U’Ren, J.M. (2007). Global genetic population structure of Bacillus anthracis. PLoS ONE, 2.
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