Immunopathological Mechanisms Underlying Cardiac Damage in Chagas Disease

Author:

De Alba-Alvarado Mariana Citlalli1ORCID,Torres-Gutiérrez Elia1,Reynoso-Ducoing Olivia Alicia1,Zenteno-Galindo Edgar2ORCID,Cabrera-Bravo Margarita1ORCID,Guevara-Gómez Yolanda1,Salazar-Schettino Paz María1,Rivera-Fernández Norma1ORCID,Bucio-Torres Martha Irene1

Affiliation:

1. Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Coyoacán, México City 04510, Mexico

2. Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, Coyoacán, México City 04510, Mexico

Abstract

In Chagas disease, the mechanisms involved in cardiac damage are an active field of study. The factors underlying the evolution of lesions following infection by Trypanosoma cruzi and, in some cases, the persistence of its antigens and the host response, with the ensuing development of clinically observable cardiac damage, are analyzed in this review.

Funder

UNAM, DGAPA/PAPIIT

Publisher

MDPI AG

Subject

Infectious Diseases,Microbiology (medical),General Immunology and Microbiology,Molecular Biology,Immunology and Allergy

Reference95 articles.

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2. World Health Organization (2009). Enfermedad de Chagas: Control y eliminación, World Health Organization.

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2. Development of Novel Drugs for the Treatment of Chagas Disease;Current Topics in Zoonoses [Working Title];2023-09-10

3. Immunopathogenesis in Trypanosoma cruzi infection: a role for suppressed macrophages and apoptotic cells;Frontiers in Immunology;2023-08-17

4. What Do You Need to Know before Studying Chagas Disease? A Beginner’s Guide;Tropical Medicine and Infectious Disease;2023-07-10

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