First Report of Plasmid-Mediated Macrolide-Clindamycin-Tetracycline Resistance in a High Virulent Isolate of Cutibacterium acnes ST115

Author:

Rana Md Shohel1ORCID,Kim Jungmin12ORCID,Kim Shukho12ORCID

Affiliation:

1. Department of Biomedical Sciences, The Graduate School, Kyungpook National University, Daegu 41944, Republic of Korea

2. Department of Microbiology, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea

Abstract

Cutibacterium acnes, a prevalent skin commensal, has emerged as a significant global challenge due to its widespread antibiotic resistance. To investigate the antibiotic resistance mechanisms and clinical characterization of C. acnes in Korea, we collected 22 clinical isolates from diverse patient specimens obtained from the National Culture Collection for Pathogens across Korea. Among the isolates, KB112 isolate was subjected to whole genome sequencing due to high resistance against clindamycin, erythromycin, tetracycline, doxycycline, and minocycline. The whole genome analysis of KB112 isolate revealed a circular chromosome of 2,534,481 base pair with an average G + C content of 60.2% with sequence type (ST) 115, harboring the potential virulent CAMP factor pore-forming toxin 2 (CAMP2), the multidrug resistance ABC transporter ATP-binding protein YknY, and the multidrug efflux protein YfmO. The genomic sequence also showed the existence of a plasmid (30,947 bp) containing the erm(50) and tet(W) gene, which confer resistance to macrolide–clindamycin and tetracycline, respectively. This study reports plasmid-mediated multi-drug resistance of C. acnes for the first time in Korea.

Funder

Biomedical Research Institute grant, Kyungpook National University Hospital

Publisher

MDPI AG

Subject

Infectious Diseases,Microbiology (medical),General Immunology and Microbiology,Molecular Biology,Immunology and Allergy

Reference20 articles.

1. Complete genome sequence of Cutibacterium acnes KCOM 1861 isolated from a human jaw osteomyelitis lesion;Park;Korean J. Microbiol.,2017

2. Japanese Dermatological Association Guidelines: Guidelines for the treatment of acne vulgaris 2017;Hayashi;J. Dermatol.,2018

3. Antimicrobial susceptibility and characterization of Propionibacterium acnes by multilocus sequence typing and repetitive-sequence-based PCR;Kim;J. Bacteriol. Virol.,2016

4. Propionibacterium acnes Susceptibility and Correlation with Hemolytic Phenotype;Wright;Infect. Dis.,2016

5. Correlation between hemolytic profile and phylotype of Cutibacterium acnes (formerly Propionibacterium acnes) and orthopedic implant infection;Lee;Shoulder Elbow.,2020

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