Adaptive Cellular Immunity against African Swine Fever Virus Infections

Author:

Schäfer AlexanderORCID,Franzoni GiuliaORCID,Netherton Christopher L.ORCID,Hartmann Luise,Blome SandraORCID,Blohm UlrikeORCID

Abstract

African swine fever virus (ASFV) remains a threat to global pig populations. Infections with ASFV lead to a hemorrhagic disease with up to 100% lethality in Eurasian domestic and wild pigs. Although myeloid cells are the main target cells for ASFV, T cell responses are impacted by the infection as well. The complex responses remain not well understood, and, consequently, there is no commercially available vaccine. Here, we review the current knowledge about the induction of antiviral T cell responses by cells of the myeloid lineage, as well as T cell responses in infected animals, recent efforts in vaccine research, and T cell epitopes present in ASFV.

Funder

Department for Environment Food and Rural Affairs

UK Research and Innovation

European Union’s Horizon 2020

Publisher

MDPI AG

Subject

Infectious Diseases,Microbiology (medical),General Immunology and Microbiology,Molecular Biology,Immunology and Allergy

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