Pre-or co-SARS-CoV-2 Infections Significantly Increase Severe Dengue Virus Disease Criteria: Implications for Clinicians-Reference-Cited by-同舟云学术

Pre-or co-SARS-CoV-2 Infections Significantly Increase Severe Dengue Virus Disease Criteria: Implications for Clinicians

Published:2024-07-10 Issue:7 Volume:13 Page:573
ISSN:2076-0817
Container-title:Pathogens
language:en
Short-container-title:Pathogens

Author:

Bukhari Moeen Hamid¹,Annan Esther²,Haque Ubydul³⁴,Arango Pedro⁵,Falconar Andrew K. I.⁶^ORCID,Romero-Vivas Claudia M.⁶^ORCID

Affiliation:

1. Department of Statistics, Quaid-i-Azam University, Islamabad 45320, Pakistan

2. Centre for Health and Wellbeing, School of Public and International Affairs, Princeton University, Princeton, NJ 08544, USA

3. Rutgers Global Health Institute, New Brunswick, NJ 08901, USA

4. Department of Biostatistics and Epidemiology, School of Public Health, Rutgers University, Piscataway, NJ 08901, USA

5. District Department of Health of Barranquilla, Barranquilla 080003, Colombia

6. Laboratory of Tropical Diseases, Department of Medicine, Health Division, Universidad del Norte, Barranquilla 080003, Colombia

Abstract

Few studies have investigated whether SARS-CoV-2 infections increase the incidence of dengue haemorrhagic fever/shock syndrome (DHF/DSS) and/or severe dengue (SD) in dengue virus (DENV)-infected patients. This study was performed on a site with high incidences of classical dengue, but relatively few DHF/DSS or SD cases as defined by the WHO 1997 or 2009 criteria, respectively. Clinical, haematological/biochemical, and viral diagnostic data were collected from febrile patients before, during, and after the COVID-19 epidemic to assess whether (a) DENV-infected patients with prior SARS-CoV-2 infections or (b) DENV-SARS-CoV-2-co-infected patients had increased incidences of SD/DHF/DSS using logistic regression and machine learning models. Higher numbers of DHF/DSS/SD occurred during the COVID-19 epidemic, particularly in males and 18–40-year-olds. Significantly increased symptoms in the DENV-SARS-CoV-2-co-infected cases were (a) haemoconcentration (p < 0.0009) and hypotension (p < 0.0005) (DHF/DSS and SD criteria), (b) thrombocytopenia and mucosal bleeding (DHF/DSS-criteria), (c) abdominal pain, persistent vomiting, mucosal bleeding, and thrombocytopenia (SD warning signs) and (d) dyspnoea, but without fluid accumulation. DENV-infected patients with prior SARS-CoV-2 infections had significantly increased incidences of thrombocytopenia (DHF/DSS-criteria) and/or abdominal pain and persistent vomiting and also thrombocytopenia (SD warning signs), but without significant haemoconcentration or hypotension. DENV-SARS-CoV-2 co-infections significantly increased the incidence of DHF/DSS/SD, while DENV-infected patients with prior SARS-CoV-2 infections displayed significantly increased incidences of thrombocytopenia (DHF/DSS-criteria) and three important SD warning signs, which are therefore very important for health workers/clinicians in assessing patients’ DHF/DSS/SD risk factors and planning their optimal therapies.

Publisher

MDPI AG

Link

https://www.mdpi.com/2076-0817/13/7/573/pdf

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