Post-COVID-19 Syndrome in Neurology Patients: A Single Center Experience

Author:

Hegna Elena1,Rački Valentino23ORCID,Hero Mario23,Papić Eliša23,Rožmarić Gloria2,Radović Klara4ORCID,Komen Vita2,Bralić Marina23,Škifić Marina Legac23,Bonifačić David23,Tomić Zoran2,Perković Olivio23,Vuletić Vladimira23

Affiliation:

1. Department of Neurology, General Hospital Pula, 52100 Pula, Croatia

2. Department of Neurology, Clinical Hospital Center Rijeka, 51000 Rijeka, Croatia

3. Department of Neurology, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia

4. Department of Emergency Medicine, University Hospital Center Rijeka, 51000 Rijeka, Croatia

Abstract

Our aim was to determine the frequency and characteristics of neurological post-COVID-19 syndrome and the diagnostic and therapeutic measures that were used for the treatment of these patients. Data were collected for 243 patients examined during the period of 11 May 2021 to 22 June 2022. The inclusion criteria were COVID-19 illness and neurological symptoms associated with COVID-19. The exclusion criteria were non-neurological symptoms, patients who did not suffer from COVID-19, and symptoms that occurred after vaccination against the SARS-CoV-2 virus. Data for 227 patients with neurological post-COVID-19 symptoms were analyzed. Most patients presented with multiple symptoms, most often headache, cognitive impairment, loss of smell, paresthesia, fatigue, dizziness, and insomnia. Patients were most often referred for consultative examinations, neuroradiological imaging, and EEG. The therapy was mostly symptomatic. Most patients had no change in their symptoms on follow-up visits (53.21%), while positive outcome was found in 44.95% of patients. This study found that neurological post-COVID-19 syndrome appears to be more common in women, and generally, the most common symptoms are headache and cognitive impairment. The gender distribution of symptoms was clearly visible and should be further investigated. There is a need for longitudinal follow-up studies to better understand the disease dynamic.

Publisher

MDPI AG

Subject

Infectious Diseases,Microbiology (medical),General Immunology and Microbiology,Molecular Biology,Immunology and Allergy

Reference47 articles.

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3. Mathieu, E., Ritchie, H., Rodés-Guirao, L., Appel, C., Giattino, C., Hasell, J., Macdonald, B., Dattani, S., Beltekian, D., and Ortiz-Ospina, E. (2020). Coronavirus Pandemic (COVID-19). Our World Data, Available online: https://ourworldindata.org/coronavirus.

4. Menges, D., Ballouz, T., Anagnostopoulos, A., Aschmann, H.E., Domenghino, A., Fehr, J.S., and Puhan, M.A. (2021). Burden of Post-COVID-19 Syndrome and Implications for Healthcare Service Planning: A Population-Based Cohort Study. PLoS ONE, 16.

5. (2021). Post-COVID-19 Syndrome: In It for the Long Haul. EBioMedicine, 67, 103424.

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