Abstract
Vaccination with Bacillus Calmette–Guérin (BCG) constituted a major advance in the prevention of human tuberculosis (TB) in the beginning of the past century. BCG has also a clear potential for use in animals and, in particular, in the main domestic species subjected to TB control programs, cattle. Nowadays, the use of BCG vaccination against TB in cattle is not permitted by European Union legislation because BCG can induce a cellular immune response producing diagnostic interference in the eradication programs based on tuberculin single and comparative intradermal tests imposed worldwide. In this review, we recall the history of TB vaccination as well as different vaccine trials and the response to vaccination in both domestic and wild animals. Promising potential inactivated vaccines are also reviewed. Research studies are mainly focused to improve vaccine efficacy, and at the same time to ensure its easy administration, safety and stability in the environment. Great challenges remain, particularly in terms of vaccine candidates and also in the acceptance of vaccination. Vaccination should be included in a strategic plan for integrated control of TB under a “one health” perspective, which also includes other measures such as improved biosafety on farms to avoid or decrease contact between domestic and wild animals or control of wildlife reservoirs to avoid overabundance that may favor infection maintenance.
Funder
Junta de Castilla- La Mancha
Gobierno del Principado de Asturias
Subject
Infectious Diseases,Microbiology (medical),General Immunology and Microbiology,Molecular Biology,Immunology and Allergy
Reference181 articles.
1. The history of tuberculosis: From the first historical records to the isolation of Koch’s bacillus;Barberis;J. Prev. Med. Hyg.,2017
2. The Concept of Immunity. History and Applications. Immunol. Course Med. Sch. Univ. Paviahttp://nfs.unipv.it/nfs/minf/dispense/immunology/immun.html
3. La vaccination préventive contre la tuberculose par le “BCG”;Calmette;Am. J. Public Health Nations Health,1928
4. History of BCG Vaccine;Luca;Maedica (Buchar),2013
5. Evolution and Strain Variation in BCG;Abdallah;Adv. Exp. Med. Biol,2017
Cited by
15 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献