Targeted Protein Degradation: Clinical Advances in the Field of Oncology

Author:

Salama Abdelrahman K. A. A.,Trkulja Marija V.,Casanova EmilioORCID,Uras Iris Z.ORCID

Abstract

The field of targeted protein degradation (TPD) is a rapidly developing therapeutic modality with the promise to tame disease-relevant proteins in ways that are difficult or impossible to tackle with other strategies. While we move into the third decade of TPD, multiple degrader drugs have entered the stage of the clinic and many more are expected to follow. In this review, we provide an update on the most recent advances in the field of targeted degradation with insights into possible clinical implications for cancer prevention and treatment.

Funder

Fonds der Stadt Wien für innovative interdisziplinäre Krebsforschung

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

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