Abstract
The role of vitamin D in atopic dermatitis (AD) is controversial. Conflicting data could be due to the use of inadequate markers for assessing vitamin D status. So far, directly measured free 25(OH)D concentrations have not been reported in AD patients. Ten adults with AD were treated with narrow band ultraviolet light B (NB-UVB) for 10–12 weeks. SCORing atopic dermatitis (SCORAD) and the visual analogue scale (VAS) were used to assess disease severity before and after NB-UVB therapy. Total and free 25(OH)D and 1,25(OH)2D serum levels were analyzed before and after treatment. Free 25(OH)D concentrations were measured with a two-step immunosorbent assay (ELISA). The majority of patients had sufficient levels of 25(OH)D before treatment (mean 76.4 nmol/L). Mean free 25(OH)D was 11.9 pmol/L and mean 1,25(OH)2D was 108.9 pmol/L. Median SCORAD decreased from 37.1 to 19.8 and VAS improved significantly after phototherapy. Total and free 25(OH)D increased in all subjects. No correlations between disease severity and vitamin D levels were found. There was no correlation between total and free 25(OH)D levels. Larger studies are needed to test the applicability of the free hormone hypothesis in AD pathogenesis.
Funder
The Welander-Finsen Foundation
The Göteborg Medical Society
The Swedish state under the agreement between the Swedish government and the county councils, the ALF-agreement
The Swedish Society of Medicine
Reference39 articles.
1. Atopic Dermatitis;Langan;Lancet Lond. Engl.,2020
2. ISAAC Phase One Study Group Climate and the Prevalence of Symptoms of Asthma, Allergic Rhinitis, and Atopic Eczema in Children;Weiland;Occup. Environ. Med.,2004
3. Low Vitamin D Levels Are Associated with Atopic Dermatitis, but Not Allergic Rhinitis, Asthma, or IgE Sensitization, in the Adult Korean Population;Cheng;J. Allergy Clin. Immunol.,2014
4. Association of Serum 25-Hydroxyvitamin D with Serum IgE Levels in Korean Adults;Kang;Auris. Nasus. Larynx,2016
5. Kim, M.J., Kim, S.-N., Lee, Y.W., Choe, Y.B., and Ahn, K.J. (2016). Vitamin D Status and Efficacy of Vitamin D Supplementation in Atopic Dermatitis: A Systematic Review and Meta-Analysis. Nutrients, 8.
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