Hydroxyapatite Particles—Directing the Cellular Activity in Bone Regeneration Processes: An Up-To-Date Review

Abstract

Tissue engineering has evolved quickly over the years and provided three generations of scaffolds for bone tissue applications. Numerous materials have been used to induce the desired effect at cellular levels. Mechano-transduction is a phenomenon which is now gaining the attention and focus of tissue engineering researchers. The idea of controlling the cellular fate and inducing a proper response of the human body in contact with different tissue-engineered systems is now under investigation. Moreover, in order to avoid the appearance of on-site infections and the need for a second surgery, scaffolds with dual functionality are now being developed. Hydroxyapatite (HA) is an intensively studied material in this field and various combinations are under examination for the development of such scaffolds. Various techniques were exploited over the years for HA scaffold production, in order to obtain the most accurate matrix which can mimic the native bone tissue and restore its function. Biomimetic scaffolds aim to direct the cellular fate by imitating the natural structure of the bone tissue in terms of porosity, topography, composition, and surface properties. HA particles are exploited in bone tissue engineering in many forms, such as pure or composite scaffolds or reinforcement agents. In this regard, the aim of this review is to offer a current state of art about the use and synthesis of hydroxyapatite particles and their interaction with the physiological media under certain circumstances.