An Ensemble Classifier to Predict Protein–Protein Interactions by Combining PSSM-based Evolutionary Information with Local Binary Pattern Model

Abstract

Protein plays a critical role in the regulation of biological cell functions. Among them, whether proteins interact with each other has become a fundamental problem, because proteins usually perform their functions by interacting with other proteins. Although a large amount of protein–protein interactions (PPIs) data has been produced by high-throughput biotechnology, the disadvantage of biological experimental technique is time-consuming and costly. Thus, computational methods for predicting protein interactions have become a research hot spot. In this research, we propose an efficient computational method that combines Rotation Forest (RF) classifier with Local Binary Pattern (LBP) feature extraction method to predict PPIs from the perspective of Position-Specific Scoring Matrix (PSSM). The proposed method has achieved superior performance in predicting Yeast, Human, and H. pylori datasets with average accuracies of 92.12%, 96.21%, and 86.59%, respectively. In addition, we also evaluated the performance of the proposed method on the four independent datasets of C. elegans, H. pylori, H. sapiens, and M. musculus datasets. These obtained experimental results fully prove that our model has good feasibility and robustness in predicting PPIs.