Impact of ZrO2 Content on the Formation of Sr-Enriched Phosphates in Al2O3/ZrO2 Nanocomposites for Bone Tissue Engineering-Reference-Cited by-同舟云学术

Impact of ZrO2 Content on the Formation of Sr-Enriched Phosphates in Al2O3/ZrO2 Nanocomposites for Bone Tissue Engineering

Published:2024-04-19 Issue:8 Volume:17 Page:1893
ISSN:1996-1944
Container-title:Materials
language:en
Short-container-title:Materials

Author:

Nunes Fabio Caixeta¹^ORCID,Santos Sarah Ingrid Pinto²^ORCID,Colnago Luiz Alberto³^ORCID,Hammer Peter⁴^ORCID,Ferreira Julieta Adriana⁵,Ambrósio Carlos Eduardo²^ORCID,Pallone Eliria Maria¹⁶

Affiliation:

1. Postgraduate Programme in Materials Science and Engineering, Faculty of Animal Science and Food Engineering (FZEA), University of São Paulo (USP), Av. Duque de Caxias Norte, 225, Pirassununga 13635-900, SP, Brazil

2. Department of Veterinary Medicine, Faculty of Animal Science and Food Engineering (FZEA), University of São Paulo (USP), Pirassununga 13635-900, SP, Brazil

3. Brazilian Agricultural Research Corporation, EMBRAPA Instrumentation, Rua Quinze de Novembro, 1500/1501, São Carlos 13561-206, SP, Brazil

4. Institute of Chemistry, São Paulo State University (UNESP), Araraquara 14800-900, SP, Brazil

5. Fundação Hermínio Ometto, Fundação Hermínio Ometto (FHO), Av. Dr. Maximiliano Baruto, 500, Araras 13607-339, SP, Brazil

6. Department of Biosystem Engineering, Faculty of Animal Science and Food Engineering (FZEA), University of São Paulo (USP), Pirassununga 13635-900, SP, Brazil

Abstract

This study investigates the profound impact of the ZrO2 inclusion volume on the characteristics of Al2O3/ZrO2 nanocomposites, particularly influencing the formation of calcium phosphates on the surface. This research, aimed at advancing tissue engineering, prepared nanocomposites with 5, 10, and 15 vol% ZrO2, subjecting them to chemical surface treatment for enhanced calcium phosphate deposition sites. Biomimetic coating with Sr-enriched simulated body fluid (SBF) further enhanced the bioactivity of nanocomposites. While the ZrO2 concentration heightened the oxygen availability on nanocomposite surfaces, the quantity of Sr-containing phosphate was comparatively less influenced than the formation of calcium phosphate phases. Notably, the coated nanocomposites exhibited a high cell viability and no toxicity, signifying their potential in bone tissue engineering. Overall, these findings contribute to the development of regenerative biomaterials, holding promise for enhancing bone regeneration therapies.

Funder

São Paulo Research Foundation

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

undação de Estudos Agrários Luiz de Queiroz (Fealq) and University of São Paulo

Publisher

MDPI AG

Link

https://www.mdpi.com/1996-1944/17/8/1893/pdf

Reference67 articles.

1. Robocasting and Surface Functionalization with Highly Bioactive Glass of ZrO2 Scaffolds for Load Bearing Applications;Gaddam;J. Am. Ceram. Soc.,2021

2. Engineering Multifunctional Bioactive Citrate-Based Biomaterials for Tissue Engineering;Wang;Bioact. Mater.,2023

3. Structural Ceramic Nanocomposites: A Review of Properties and Powders’ Synthesis Methods;Palmero;Nanomaterials,2015

4. Poznyak, A., Knörnschild, G., Karoza, A., Norek, M., and Pligovka, A. (2021). Peculiar Porous Aluminum Oxide Films Produced via Electrochemical Anodizing in Malonic Acid Solution with Arsenazo-I Additive. Materials, 14.

5. Anodic alumina prepared in aqueous solutions of chelating complex zinc and cobalt compounds;Poznyak;Tech. Phys.,2022