Transcranial Photosensitizer-Free Laser Treatment of Glioblastoma in Rat Brain

Author:

Semyachkina-Glushkovskaya Oxana12ORCID,Sokolovski Sergey3ORCID,Fedosov Ivan4,Shirokov Alexander25ORCID,Navolokin Nikita26ORCID,Bucharskaya Alla6ORCID,Blokhina Inna2ORCID,Terskov Andrey2,Dubrovski Alexander4,Telnova Valeria2ORCID,Tzven Anna2,Tzoy Maria4ORCID,Evsukova Arina2,Zhlatogosrkaya Daria2,Adushkina Viktoria2,Dmitrenko Alexander2,Manzhaeva Maria2,Krupnova Valeria2,Noghero Alessio7,Bragin Denis78ORCID,Bragina Olga78,Borisova Ekaterina9ORCID,Kurths Jürgen121011,Rafailov Edik3ORCID

Affiliation:

1. Physics Department, Humboldt University, Newtonstrasse 15, 12489 Berlin, Germany

2. Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia

3. Optoelectronics and Biomedical Photonics Group, AIPT, Aston University, Birmingham B4 7ET, UK

4. Physics Department, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia

5. Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences, Prospekt Entuziastov 13, 410049 Saratov, Russia

6. Department of Pathological Anatomy, Saratov Medical State University, Bolshaya Kazachaya Str. 112, 410012 Saratov, Russia

7. Lovelace Biomedical Research Institute, Albuquerque, NM 87108, USA

8. Department of Neurology, School of Medicine, University of New Mexico, Albuquerque, NM 87131, USA

9. Institute of Electronics, Bulgarian Academy of Sciences, Tsarigradsko Chaussee Blvd. 72, 1784 Sofia, Bulgaria

10. Potsdam Institute for Climate Impact Research, Telegrafenberg A31, 14473 Potsdam, Germany

11. Centre for Analysis of Complex Systems, Sechenov First Moscow State Medical University Moscow, 119991 Moscow, Russia

Abstract

Over sixty years, laser technologies have undergone a technological revolution and become one of the main tools in biomedicine, particularly in neuroscience, neurodegenerative diseases and brain tumors. Glioblastoma is the most lethal form of brain cancer, with very limited treatment options and a poor prognosis. In this study on rats, we demonstrate that glioblastoma (GBM) growth can be suppressed by photosensitizer-free laser treatment (PS-free-LT) using a quantum-dot-based 1267 nm laser diode. This wavelength, highly absorbed by oxygen, is capable of turning triplet oxygen to singlet form. Applying 1267 nm laser irradiation for a 4 week course with a total dose of 12.7 kJ/cm2 firmly suppresses GBM growth and increases survival rate from 34% to 64%, presumably via LT-activated apoptosis, inhibition of the proliferation of tumor cells, a reduction in intracranial pressure and stimulation of the lymphatic drainage and clearing functions. PS-free-LT is a promising breakthrough technology in non- or minimally invasive therapy for superficial GBMs in infants as well as in adult patients with high photosensitivity or an allergic reaction to PSs.

Funder

Russian Science Foundation

Russian Ministry of Science and Higher Education

NIH

HE Pathfinder GlioLight project

IBPPM RAS

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. New insights into phototherapy of glioblastoma: the meningeal lymphatics and sleep;The European Physical Journal Special Topics;2024-01-25

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