The Role of Acyl-CoA β-Oxidation in Brain Metabolism and Neurodegenerative Diseases

Author:

Szrok-Jurga Sylwia1ORCID,Turyn Jacek1ORCID,Hebanowska Areta1,Swierczynski Julian2,Czumaj Aleksandra3,Sledzinski Tomasz3ORCID,Stelmanska Ewa1ORCID

Affiliation:

1. Department of Biochemistry, Faculty of Medicine, Medical University of Gdansk, 80-211 Gdansk, Poland

2. Institute of Nursing and Medical Rescue, State University of Applied Sciences in Koszalin, 75-582 Koszalin, Poland

3. Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Medical University of Gdansk, 80-211 Gdansk, Poland

Abstract

This review highlights the complex role of fatty acid β-oxidation in brain metabolism. It demonstrates the fundamental importance of fatty acid degradation as a fuel in energy balance and as an essential component in lipid homeostasis, brain aging, and neurodegenerative disorders.

Funder

Medical University of Gdansk

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Reference93 articles.

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3. Roberts, E.L. (2007). Handbook of Neurochemistry and Molecular Neurobiology: Brain Energetics, Springer. Integration of Molecular and Cellular Processes.

4. Loss of Fatty Acid Degradation by Astrocytic Mitochondria Triggers Neuroinflammation and Neurodegeneration;Mi;Nat. Metab.,2023

5. Rapid Uptke of [1-14C] Acetate by the Adult Rat Brain 15 Seconds after Carotid Injection;Dhopeshwarkar;Biochim. Et Biophys. Acta (BBA)/Lipids Lipid Metab.,1971

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. The Physiological and Pathological Role of Acyl-CoA Oxidation;International Journal of Molecular Sciences;2023-10-03

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