Proteomic Approaches to Unravel the Molecular Dynamics of Early Pregnancy in Farm Animals: An In-Depth Review

Author:

Jamwal Shradha1,Jena Manoj Kumar2ORCID,Tyagi Nikunj1ORCID,Kancharla Sudhakar3,Kolli Prachetha4,Mandadapu Gowtham3,Kumar Sudarshan1ORCID,Mohanty Ashok Kumar5

Affiliation:

1. Proteomics and Structural Biology Lab, Animal Biotechnology Centre, National Dairy Research Institute, Karnal 132001, Haryana, India

2. Department of Biotechnology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara 144411, Punjab, India

3. Devansh Lab Werks, 234 Aquarius Drive, Homewood, AL 35209, USA

4. Microgen Health Inc., 14225 Sullyfield Cir Suite E, Chantilly, VA 20151, USA

5. ICAR–Central Institute for Research on Cattle, Meerut Cantt 250001, Uttar Pradesh, India

Abstract

Infertility is a major problem in farm animals, which has a negative economic effect on farm industries. Infertility can be defined as the inability of animals to achieve a successful pregnancy. Early pregnancy is crucial to establish a successful pregnancy, and it is reported that 70–80% and 20–30% of total embryonic loss occur in cattle and pigs, respectively, during the first month of pregnancy. The advanced high-throughput proteomics techniques provide valuable tools for in-depth understanding of the implantation process in farm animals. In the present review, our goal was to compile, assess, and integrate the latest proteomic research on farm animals, specifically focused on female reproduction, which involves endometrial tissues, uterine fluids, oviductal fluids, and microRNAs. The series of studies has provided in-depth insights into the events of the implantation process by unfolding the molecular landscape of the uterine tract. The discussed data are related to pregnant vs. non-pregnant animals, pregnancy vs. oestrous cycle, different days of the early pregnancy phase, and animals with uterine infections affecting reproduction health. Some of the studies have utilized non-invasive methods and in vitro models to decipher the molecular events of embryo-maternal interaction. The proteomics data are valuable sources for discovering biomarkers for infertility in ruminants and new regulatory pathways governing embryo-uterine interaction, endometrium receptivity, and embryonic development. Here, we envisage that the identified protein signatures can serve as potential therapeutic targets and biomarkers to develop new therapeutics against pregnancy diseases.

Publisher

MDPI AG

Subject

Cell Biology,Developmental Biology,Molecular Biology

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