Affiliation:
1. Faculty of Chemistry and Chemical Technology, University of Ljubljana, Večna pot 113, 1000 Ljubljana, Slovenia
Abstract
Among the methods used for the synthesis of functionalized heterocyclic compounds, photochemistry has gained immense popularity due to the reactivity of intermediates in photoinduced reactions. In this study, we report on the effect of diaryl disulfides as hydrogen atom transfer catalysts on the photoinduced transformations of pyrazolo[1,2-a]pyrazolones. After excitation with visible light, these compounds are susceptible to C–N bond cleavage, followed by intermolecular hydrogen atom abstraction. By modifying the reaction conditions, we have developed two novel methods for the synthesis of highly substituted pyrazoles.
Funder
Slovenian Research Agency
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Reference14 articles.
1. Recently reported biological activities of pyrazole compounds;Faria;Bioorg. Med. Chem.,2017
2. Action of Phenylpyrazole Insecticides at the GABA-Gated Chloride Channel;Cole;Pestic. Biochem. Phys.,1993
3. Discovery, synthesis and molecular corroborations of medicinally important novel pyrazoles; drug efficacy determinations through in silico, in vitro and cytotoxicity validations;Thangarasu;Bioorg. Chem.,2019
4. Unveiling novel diphenyl-1H-pyrazole based acrylates tethered to 1,2,3-triazole as promising apoptosis inducing cytotoxic and anti-inflammatory agents;Khan;Bioorg. Chem.,2019
5. Targeting hepatocellular carcinoma: Synthesis of new pyrazole-based derivatives, biological evaluation, DNA binding, and molecular modeling studies;Omran;Bioorg. Chem.,2019