SARS-CoV-2-Related Parotitis in Children: A Narrative-Focused Review

Author:

Marino Andrea1ORCID,Cacciaguerra Giovanni2ORCID,Sangiorgio Giuseppe3ORCID,Maniaci Antonino4ORCID,La Via Luigi5ORCID,Cocuzza Salvatore6ORCID,Stracquadanio Stefano3,Leonardi Roberta2ORCID,Spampinato Serena1,Cacopardo Bruno1,Pavone Piero7ORCID,Nunnari Giuseppe1ORCID

Affiliation:

1. Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, University of Catania, ARNAS Garibaldi Hospital, 95122 Catania, Italy

2. Section of Pediatrics and Child Neuropsychiatry, School of Specialization in Pediatrics, Department of Clinical and Experimental Medicine, University of Catania, 95124 Catania, Italy

3. Department of Biomedical and Biotechnological Sciences, University of Catania, Via Santa Sofia 97, 95123 Catania, Italy

4. Department of Medicine and Surgery, University of Enna “Kore”, 94100 Enna, Italy

5. Department of Anesthesia and Intensive Care, University Hospital Policlinico—San Marco, 24046 Catania, Italy

6. Department of Medical and Surgical Sciences and Advanced Technologies “GF Ingrassia”, ENT Section, University of Catania, 95125 Catania, Italy

7. Department of Clinical and Experimental Medicine, Section of Pediatrics and Child Neuropsychiatry, University Hospital “Policlinico G. Rodolico”, 95125 Catania, Italy

Abstract

The COVID-19 pandemic has revealed a diverse spectrum of clinical manifestations in the pediatric population, including the rare but notable presentation of unilateral parotitis. This comprehensive review explores the complexities surrounding SARS-CoV-2-associated unilateral parotitis in children. It addresses the initial clinical presentation, diagnostic challenges, treatment strategies, and the wider epidemiological impacts of this unusual symptom. The review synthesizes the available literature, providing insights into the pathophysiological mechanisms underlying this atypical manifestation and its implications for pediatric healthcare during the pandemic. Through the rigorous analysis of reported cases, this study underscores the need for increased awareness and a broad differential diagnosis among clinicians. It also emphasizes the importance of continued research to delineate the full clinical spectrum of COVID-19 in children.

Publisher

MDPI AG

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3. Cosentino, F., Moscatt, V., Marino, A., Pampaloni, A., Scuderi, D., Ceccarelli, M., Benanti, F., Gussio, M., Larocca, L., and Boscia, V. (2022). Clinical Characteristics and Predictors of Death among Hospitalized Patients Infected with SARS-CoV-2 in Sicily, Italy: A Retrospective Observational Study. Biomed. Rep., 16.

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