Comparison of Clinical Features, Complete Blood Count Parameters, and Outcomes between Two Distinct Waves of COVID-19: A Monocentric Report from Italy

Author:

Fois Sara SolveigORCID,Zinellu Elisabetta,Zinellu AngeloORCID,Merella Michela,Pau Maria Carmina,Carru CiriacoORCID,Fois Alessandro GiuseppeORCID,Pirina PietroORCID

Abstract

Background: Since the beginning of the SARS-CoV-2 pandemic, the ability to predict the trajectory of the disease has represented a major challenge for clinicians. There is recent evidence that complete blood cell count (CBC)-derived inflammation indexes have predictive value in COVID-19. We aimed to describe any changes in the clinical features, CBC-derived ratios, and outcomes of patients admitted to our hospital across two temporally distinct waves. Methods: We retrospectively assessed and compared the clinical characteristics and blood cell count values of patients hospitalized during the second and fourth waves of COVID-19, and explored any outcome differences in terms of the level of respiratory support required and transfer to intensive care. Results: We observed that fourth-wave patients were older, less male-predominant, and carried more comorbidities compared to the second-wave patients but, nevertheless, experienced more favorable outcomes. A strong internal correlation was documented for both waves between outcomes and CBC-derived ratios, with the fourth-wave cases displaying lower admission values of the neutrophil-to-lymphocyte ratio (NLR), derived NLR (dNLR), platelet-to-lymphocyte ratio (PLR), and systemic inflammation index (SII). No significant differences were found for lymphocyte-to-monocyte ratio (LMR), systemic inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI). Conclusions: We observed that both admission values of CBC-derived indexes and adverse respiratory outcomes decreased from the second to the fourth wave of COVID-19. These data represent a contribution to the existing knowledge on the role of CBC-derived indexes as a potential tool to help clinicians to quickly differentiate in-hospital patients at increased risk of serious illness and death.

Publisher

MDPI AG

Subject

Health Information Management,Health Informatics,Health Policy,Leadership and Management

Reference54 articles.

1. World Health Organization (2022, July 01). WHO Director-General’s Opening Remarks at the Media Briefing on COVID-19—11 March 2020. Available online: https://www.who.int/director-general/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19---11-march-2020.

2. Beyond COVID-19: A Cross-Sectional Study in Italy Exploring the COVID Collateral Impacts on Healthcare Services;Gualano;Health Policy,2021

3. COVID-19 Impact on Early Career Investigators: A Call for Action;Levine;Nat. Rev. Cancer,2020

4. Impact of Long-Term Home Quarantine on Mental Health and Physical Activity of People in Shanghai during the COVID-19 Pandemic;Zhu;Front. Psychiatry,2022

5. Lockdowns due to COVID-19 Threaten Ph.D. Students’ and Early-Career Researchers’ Careers;Paula;Nat. Ecol. Evol.,2020

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