Serious Long-Term Effects of Head and Neck Cancer from the Survivors’ Point of View-Reference-Cited by-同舟云学术

Serious Long-Term Effects of Head and Neck Cancer from the Survivors’ Point of View

Published:2023-03-21 Issue:6 Volume:11 Page:906
ISSN:2227-9032
Container-title:Healthcare
language:en
Short-container-title:Healthcare

Author:

Taylor Katherine J.¹^ORCID,Amdal Cecilie D.²³,Bjordal Kristin³⁴^ORCID,Astrup Guro L.²,Herlofson Bente B.⁵⁶,Duprez Fréderic⁷,Gama Ricardo R.⁸^ORCID,Jacinto Alexandre⁹^ORCID,Hammerlid Eva¹⁰,Scricciolo Melissa¹¹^ORCID,Jansen Femke¹²¹³,Verdonck-de Leeuw Irma M.¹²¹³¹⁴,Fanetti Giuseppe¹⁵^ORCID,Guntinas-Lichius Orlando¹⁶^ORCID,Inhestern Johanna¹⁶¹⁷^ORCID,Dragan Tatiana¹⁸,Fabian Alexander¹⁹,Boehm Andreas²⁰^ORCID,Wöhner Ulrike²⁰^ORCID,Kiyota Naomi²¹^ORCID,Krüger Maximilian²²,Bonomo Pierluigi²³^ORCID,Pinto Monica²⁴^ORCID,Nuyts Sandra²⁵²⁶^ORCID,Silva Joaquim C.²⁷^ORCID,Stromberger Carmen²⁸²⁹,Tramacere Francesco³⁰,Bushnak Ayman³¹,Perotti Pietro³²,Plath Michaela³³,Paderno Alberto³⁴^ORCID,Stempler Noa³⁵,Kouri Maria³⁶^ORCID,Singer Susanne¹^ORCID

Affiliation:

1. Institute of Medical Biostatistics, Epidemiology, and Informatics, University Medical Centre Mainz, 55131 Mainz, Germany

2. Department of Oncology, Oslo University Hospital, 0372 Oslo, Norway

3. Research Support Service, Oslo University Hospital 0372 Oslo, Norway

4. Faculty of Medicine, University of Oslo, 0372 Oslo, Norway

5. Faculty of Dentistry, University of Oslo, 0455 Oslo, Norway

6. Department of Otorhinolaryngology, Oslo University Hospital, 0372 Oslo, Norway

7. Department of Radiotherapy-Oncology, Faculty of Medicine and Health Sciences—Human Structure and Repair, Ghent University Hospital, Ghent University, 9000 Ghent, Belgium

8. Department of Head and Neck Surgery, Barretos Cancer Hospital, Barretos 14784-400, SP, Brazil

9. Department of Radiation Oncology, Barretos Cancer Hospital, Barretos 14784-400, SP, Brazil

10. Department of Otorhinolaryngology-Head and Neck Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, 41345 Gothenburg, Sweden

11. Department of Radiation Oncology, Ospedale dell’Angelo, 30174 Venice, Italy

12. Department Otolaryngology-Head and Neck Surgery, Amsterdam UMC Location Vrije Universiteit, De Boelelaan 1117, 1081 HZ Amsterdam, The Netherlands

13. Cancer Center Amsterdam, Treatment and Quality of Life, 1081 HV Amsterdam, The Netherlands

14. Department Clinical, Neuro and Developmental Psychology, Vrije Universiteit Amsterdam, Van der Boechorststraat 7-9, 1081 HV Amsterdam, The Netherlands

15. Division of Radiation Oncology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081 Aviano, Italy

16. Department of Otorhinolaryngology, Jena University Hospital, 07747 Jena, Germany

17. Department of Otorhinolaryngology, Oberhavelkliniken Hennigsdorf, 16761 Hennigsdorf, Germany

18. Head and Neck Unit, Department of Radiation Oncology, Institut Jules Bordet, Université Libre de Bruxelles, 1070 Brussels, Belgium

19. Department of Radiation Oncology, University Hospital Schleswig-Holstein, 24105 Kiel, Germany

20. Department of Otorhinolaryngology, St. Georg Hospital, 04129 Leipzig, Germany

21. Cancer Center, Kobe University Hospital, Kobe 650-0017, Japan

22. Department of Oral and Maxillofacial Surgery—Plastic Surgery, University Medical Centre Mainz, 55131 Mainz, Germany

23. Radiation Oncology, Azienda Ospedaliero-Universitaria Careggi, 50134 Florence, Italy

24. Rehabilitation Medicine Unit, Strategic Health Services Department, Istituto Nazionale Tumori—IRCCS—Fondazione G. Pascale, 80131 Naples, Italy

25. Laboratory of Experimental Radiotherapy, Department of Oncology, KU Leuven, 3000 Leuven, Belgium

26. Department of Radiation Oncology, Leuven Cancer Institute, University Hospitals Leuven, 3000 Leuven, Belgium

27. Department of Otolaryngology, Head and Neck Surgery, Instituto Português de Oncologia Francisco Gentil do Porto, 4200-072 Porto, Portugal

28. Department of Radiation Oncology, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany

29. Berlin Institute of Health, 10178 Berlin, Germany

30. Department of Radiation Oncology, Azienda Sanitaria Locale, 72100 Brindisi, Italy

31. Department of Otorhinolaryngology, University Hospital Gießen und Marburg, 35392 Giessen, Germany

32. Department of Otorhinolaryngology—Head and Neck Surgery, “S. Chiara” Hospital, Azienda Provinciale per i Servizi Sanitari (APSS), 38122 Trento, Italy

33. Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Heidelberg, 69120 Heidelberg, Germany

34. Department of Otorhinolaryngology—Head and Neck Surgery, ASST Spedali Civili of Brescia, University of Brescia, 25123 Brescia, Italy

35. Oral Medicine Unit, Sheba Medical Center, Tel Hashomer, Ramat Gan 5262000, Israel

36. Dental Oncology Unit, Department of Oral Medicine and Pathology and Hospital Dentistry, Dental School, National and Kapodistrian University of Athens, 11527 Athens, Greece

Abstract

The long-term problems of head and neck cancer survivors (HNCS) are not well known. In a cross-sectional international study aimed at exploring the long-term quality of life in this population, 1114 HNCS were asked to state their two most serious long-term effects. A clinician recorded the responses during face-to-face appointments. A list of 15 example problems was provided, but a free text field was also available. A total of 1033 survivors responded to the question. The most frequent problems were ‘dry mouth’ (DM) (n = 476; 46%), ‘difficulty swallowing/eating’ (DSE) (n = 408; 40%), ‘hoarseness/difficulty speaking’ (HDS) (n = 169; 16%), and ‘pain in the head and neck’ (PHN) (n = 142; 14%). A total of 5% reported no problems. Logistic regression adjusted for age, gender, treatment, and tumor stage and site showed increased odds of reporting DM and DSE for chemo-radiotherapy (CRT) alone compared to surgery alone (odds ratio (OR): 4.7, 95% confidence interval (CI): 2.5–9.0; OR: 2.1, CI: 1.1–3.9), but decreased odds for HDS and PHN (OR: 0.3, CI: 0.1–0.6; OR: 0.2, CI: 0.1–0.5). Survivors with UICC stage IV at diagnosis compared to stage I had increased odds of reporting HDS (OR: 1.9, CI: 1.2–3.0). Laryngeal cancer survivors had reduced odds compared to oropharynx cancer survivors of reporting DM (OR: 0.4, CI: 0.3–0.6) but increased odds of HDS (OR: 7.2, CI: 4.3–12.3). This study provides evidence of the serious long-term problems among HNCS.

Funder

the European Organization for the Research and Treatment of Cancer’s Quality of Life Group

Publisher

MDPI AG

Subject

Health Information Management,Health Informatics,Health Policy,Leadership and Management

Link

https://www.mdpi.com/2227-9032/11/6/906/pdf

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