Abstract
Kaempferol, a natural flavonoid abundantly found in plants, is known to have pharmacological properties, such as anti-inflammatory and anti-cancer effects. In this study, we investigated the antiviral effects of kaempferol against a varicella-zoster virus (VZV) clinical isolate in vitro. We found that kaempferol significantly inhibited VZV replication without exhibiting cytotoxicity. Kaempferol exerted its antiviral effect at a similar stage of the VZV life cycle as acyclovir, which inhibits VZV DNA replication. Taken together, our results suggest that kaempferol inhibits VZV infection by blocking the DNA replication stage in the viral life cycle.
Funder
Korea Institute of Science and Technology
Gachon University
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
Reference36 articles.
1. Varicella zoster virus infection;Gershon;Nat. Rev. Dis. Prim.,2015
2. Depledge, D.P., Sadaoka, T., and Ouwendijk, W.J. (2018). Molecular aspects of varicella-zoster virus latency. Viruses, 10.
3. Neurological disease produced by varicella zoster virus reactivation without rash;Gilden;Curr. Top. Microbiol. Immunol.,2010
4. Immunobiology of varicella-zoster virus infection;Laing;J. Infect. Dis.,2018
5. Pathogenesis and current approaches to control of varicella-zoster virus infections;Gershon;Clin. Microbiol. Rev.,2013
Cited by
9 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献