Abstract
A phytochemical investigation of the leaves and twigs of Glycosmis pentaphylla (Rutaceae), collected in Vietnam, yielded three new compounds named glyfuran (1), glyphyllamide (2), and glyphyllazole (3), along with twenty-five known compounds (4–28). The structures of isolates were determined by IR, MS, NMR, and UV data analyses. In the anti-diabetic activity screening, (+)-isoaltholacton (4), glycoborinine (17), 2′,4′-dihydroxy-4,6′-dimethoxychalcone (24), and flavokawain A (25) simultaneously exhibited inhibition of dipeptidyl peptidase-4 (DPP4) and stimulation of the glucagon-like peptide-1 (GLP-1) secretion on the murine intestinal secretin tumor cell line (STC-1).
Funder
Ministry of Science and Technology of Taiwan
Zuoying Branch of Kaohsiung Armed Forces General Hospital
National Research Institute of Chinese Medicine
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
Reference42 articles.
1. World Health Organization (2020, August 25). Diabetes, Available online: https://www.who.int/health-topics/diabetes#tab=tab_1.
2. Health Promotion Administration, Ministry of Health and Welfare (2020, August 25). The Information about the Diabetes Patients in Taiwan, Available online: https://www.hpa.gov.tw/Pages/List.aspx?nodeid=359.
3. Diabetes mellitus as a predictor of cancer mortality in a large cohort of US adults;Coughlin;Am. J. Epidemiol.,2004
4. Antidiabetic therapies affect risk of pancreatic cancer;Li;Gastroenterology,2009
5. Traditional Chinese Medicine in the treatment of diabetes;Covington;Diabetes Spectr.,2001