Abstract
Cholera toxin B-subunit (CTxB) has emerged as one of the most widely utilized tools in membrane biology and biophysics. CTxB is a homopentameric stable protein that binds tightly to up to five GM1 glycosphingolipids. This provides a robust and tractable model for exploring membrane structure and its dynamics including vesicular trafficking and nanodomain assembly. Here, we review important advances in these fields enabled by use of CTxB and its lipid receptor GM1.
Funder
National Institutes of Health
National Science Foundation
Harrington Scholar Innovator Award
Subject
Health, Toxicology and Mutagenesis,Toxicology
Cited by
33 articles.
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