Ochratoxin A Induces Steatosis via PPARγ-CD36 Axis

Author:

Zheng Qian-Wen,Ding Xu-Fen,Cao Hui-Jun,Ni Qian-Zhi,Zhu Bing,Ma NingORCID,Zhang Feng-Kun,Wang Yi-Kang,Xu Sheng,Chen Tian-Wei,Xia Ji,Qiu Xiao-Song,Yu Dian-ZhenORCID,Xie Dong,Li Jing-JingORCID

Abstract

Ochratoxin A(OTA) is considered to be one of the most important contaminants of food and feed worldwide. The liver is one of key target organs for OTA to exert its toxic effects. Due to current lifestyle and diet, nonalcoholic fatty liver disease (NAFLD) has been the most common liver disease. To examine the potential effect of OTA on hepatic lipid metabolism and NAFLD, C57BL/6 male mice received 1 mg/kg OTA by gavage daily. Compared with controls, OTA increased lipid deposition and TG accumulation in mouse livers. In vitro OTA treatment also promoted lipid droplets accumulation in primary hepatocytes and HepG2 cells. Mechanistically, OTA prevented PPARγ degradation by reducing the interaction between PPARγ and its E3 ligase SIAH2, which led to activation of PPARγ signaling pathway. Furthermore, downregulation or inhibition of CD36, a known of PPARγ, alleviated OTA-induced lipid droplets deposition and TG accumulation. Therefore, OTA induces hepatic steatosis via PPARγ-CD36 axis, suggesting that OTA has an impact on liver lipid metabolism and may contribute to the development of metabolic diseases.

Funder

National Key R&D Program of China

National Natural Science Foundation of China

Publisher

MDPI AG

Subject

Health, Toxicology and Mutagenesis,Toxicology

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