3D-Bioprinted Gelatin Methacryloyl-Strontium-Doped Hydroxyapatite Composite Hydrogels Scaffolds for Bone Tissue Regeneration-Reference-Cited by-同舟云学术

3D-Bioprinted Gelatin Methacryloyl-Strontium-Doped Hydroxyapatite Composite Hydrogels Scaffolds for Bone Tissue Regeneration

Published:2024-07-06 Issue:13 Volume:16 Page:1932
ISSN:2073-4360
Container-title:Polymers
language:en
Short-container-title:Polymers

Author:

Codrea Cosmin Iulian¹²^ORCID,Baykara Dilruba³⁴,Mitran Raul-Augustin²^ORCID,Koyuncu Ayşe Ceren Çalıkoğlu³⁴,Gunduz Oguzhan³⁴^ORCID,Ficai Anton¹⁵⁶⁷^ORCID

Affiliation:

1. Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology Politehnica of Bucharest, 060042 Bucharest, Romania

2. Institute of Physical Chemistry “Ilie Murgulescu” of the Romanian Academy, 060021 Bucharest, Romania

3. Center for Nanotechnology & Biomaterials Application and Research (NBUAM), Marmara University, 34722 Istanbul, Turkey

4. Department of Metallurgical and Materials Engineering, Faculty of Technology, Marmara University, 34722 Istanbul, Turkey

5. National Research Center for Micro and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology POLITEHNICA Bucharest, 060042 Bucharest, Romania

6. National Centre for Food Safety, National University of Science and Technology POLITEHNICA Bucharest, 060042 Bucharest, Romania

7. Academy of Romanian Scientists, Ilfov St. 3, 50044 Bucharest, Romania

Abstract

New gelatin methacryloyl (GelMA)—strontium-doped nanosize hydroxyapatite (SrHA) composite hydrogel scaffolds were developed using UV photo-crosslinking and 3D printing for bone tissue regeneration, with the controlled delivery capacity of strontium (Sr). While Sr is an effective anti-osteoporotic agent with both anti-resorptive and anabolic properties, it has several important side effects when systemic administration is applied. Multi-layer composite scaffolds for bone tissue regeneration were developed based on the digital light processing (DLP) 3D printing technique through the photopolymerization of GelMA. The chemical, morphological, and biocompatibility properties of these scaffolds were investigated. The composite gels were shown to be suitable for 3D printing. In vitro cell culture showed that osteoblasts can adhere and proliferate on the surface of the hydrogel, indicating that the GelMA-SrHA hydrogel has good cell viability and biocompatibility. The GelMA-SrHA composites are promising 3D-printed scaffolds for bone repair.

Funder

National University of Science and Technology POLITEHNICA of Bucharest

Publisher

MDPI AG

Link

https://www.mdpi.com/2073-4360/16/13/1932/pdf

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