Neuroplastin in Neuropsychiatric Diseases

Author:

Lin Xiao,Liang Yi,Herrera-Molina RodrigoORCID,Montag DirkORCID

Abstract

Molecular mechanisms underlying neuropsychiatric and neurodegenerative diseases are insufficiently elucidated. A detailed understanding of these mechanisms may help to further improve medical intervention. Recently, intellectual abilities, creativity, and amnesia have been associated with neuroplastin, a cell recognition glycoprotein of the immunoglobulin superfamily that participates in synapse formation and function and calcium signaling. Data from animal models suggest a role for neuroplastin in pathways affected in neuropsychiatric and neurodegenerative diseases. Neuroplastin loss or disruption of molecular pathways related to neuronal processes has been linked to various neurological diseases, including dementia, schizophrenia, and Alzheimer’s disease. Here, we review the molecular features of the cell recognition molecule neuroplastin, and its binding partners, which are related to neurological processes and involved in learning and memory. The emerging functions of neuroplastin may have implications for the treatment of diseases, particularly those of the nervous system.

Funder

Federal Ministry of Education and Research

China Scholarship Council

German Academic Exchange Service

Land Sachsen-Anhalt

Publisher

MDPI AG

Subject

Genetics(clinical),Genetics

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