Abstract
Anemia is a condition in which red blood cells or the hemoglobin in the blood is lower than in healthy people. Red blood cells transport and supply oxygen needed to various organs in the human body. Anemia is caused by hypoxemia due to the lack of red blood cells and causes other serious health problems, such as heart problems, pregnancy complications, severe fatigue, or death. There are many causes of anemia, and it can be diagnosed by measuring hematocrit or hemoglobin levels in the blood. Even though there are various diagnostic devices on the market, these devices are inconvenient because their systems are bulky, heavy, expensive, or inaccurate. This study proposed a new anemia diagnostic system based on the impedance measurement of red blood cells. The proposed system consists of a test strip that collects a blood sample from the finger and a hemoglobin meter that measures the impedance of the blood and converts it into the concentration of hemoglobin. The proposed test strip that does not contain enzymes or reagents was designed in accordance with class 1 approval by the Food and Drug Administration (FDA). The hemoglobin meter was designed to include a hardware block, an algorithm block and a calibration block through empirical work. We also compared it to reference impedance to prove the accuracy of the hemoglobin meter. The experimental results with human blood indicated the superiority of the anemia diagnostic system. As a result, the overall standard deviation of impedance measurements was less than 1%, and the coefficient of variance of the proposed system was 1.7%, which was better than that of other commercial systems.
Funder
information and communications technology planning and evaluation
Subject
Electrical and Electronic Engineering,Biochemistry,Instrumentation,Atomic and Molecular Physics, and Optics,Analytical Chemistry
Reference32 articles.
1. Potential Point-of-Care Microfluidic Devices to Diagnose Iron Deficiency Anemia
2. Anemia in the emergency department: Evaluation and treatment;Janz;Emerg. Med. Pract.,2016
3. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: A systematic analysis for the Global Burden of Disease Study 2015;Lancet,2017
4. Anemia, genetic diseases, and malaria in prehistoric mainland southeast Asia
5. Anemiahttps://www.mayoclinic.org/diseases-conditions/anemia/symptoms-causes/syc-20351360
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