Clinico-Morphological Features and Immunohistochemical Profile of a Rare Case of Three Synchronous Primary Malignancies in the Female Genital Tract

Author:

Boșoteanu Mădălina12,Vodă Raluca Ioana13ORCID,Balţǎtescu Gabriela Izabela13ORCID,Aşchie Mariana13,Nurla Luana-Andreea45,Orǎşanu Cristian Ionuţ13ORCID

Affiliation:

1. Clinical Service of Pathology, “Sf. Apostol Andrei” Emergency County Hospital, 900591 Constanţa, Romania

2. Department of Pathology, Faculty of Medicine, “Ovidius” University of Constanţa, 900527 Constanța, Romania

3. Center for Research and Development of the Morphological and Genetic Studies of Malignant Pathology-CEDMOG, “Ovidius” University of Constanţa, 900591 Constanța, Romania

4. “Elias” Emergency University Hospital, Dermatovenerology Department, 011461 Bucharest, Romania

5. Institute of Doctoral Studies, Doctoral School of Medicine, “Ovidius” University of Constanţa, 900573 Constanţa, Romania

Abstract

(1) Background: Synchronous tumors are defined as tumors that occur at the same time, appearing within 2 months, according to the Surveillance Epidemiology and End Results Program, with a frequency of tertiary tumors of 0.5%. The purpose of this presentation is to report a case of three synchronous tumors of the female genital tract, given the fact that it represents a challenge both therapeutically and in demonstrating that the malignant lesions are completely different from each other. (2) Methods: We report the case of a 45 year-old patient diagnosed with three synchronous tumors developed in the genital tract: clear-cell ovarian carcinoma, uterine endometrioid adenocarcinoma, and cervical adenosquamous carcinoma. (3) Results: Total hysterectomy with bilateral anexectomy was performed and accompanied by a biopsy of the greater omentum. The evolution of the patient was favorable during chemotherapy, but she died two weeks after the completion of this treatment, from a cause secondary to the adverse effects determined by it, namely, severe thrombopenia which caused a massive lower digestive hemorrhage. (4) Conclusions: This case demonstrates the maximum importance of the involvement of adjuvant diagnostic techniques, especially when it comes to a diagnostic challenge with direct implications in the subsequent therapy of the patient.

Publisher

MDPI AG

Reference39 articles.

1. Synchronous and Metachronous Cancers: An Update;Das;Ann. Clin. Case Rep.,2017

2. Triple synchronous primary gynaecological tumours. A case report;Cir. Cir.,2016

3. Triple Synchronous Primary Malignancies of Ovary, Endometrium and Cervix—A Rare Case Report;Shah;JMSCR,2018

4. Triple Synchronous Malignancies in Genital Tract; Primary Endometrial, Ovarian and Fallopian Tube Carcinoma: A Case Report;Kan;J. Clin. Diagn. Res.,2017

5. Three primary synchronous malignancies of the uterus, cervix, and fallopian tube: A case report;Song;Medicine,2018

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