Monoclonal War: The Antibody Arsenal and Targets for Expanded Application

Author:

Rosenn Eric H.1ORCID,Benhaim Mickael2,Siegel Allison2,Stein David A.2ORCID,Leonard Joseph S.2,Katcher Erik2,Halperin Dania2,Mostel Zachary3

Affiliation:

1. Department of Biomedical Engineering, Boston University School of Engineering, Boston, MA 02215, USA

2. School of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel

3. Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA

Abstract

Advancements in sequencing and screening technology have made monoclonal antibodies more accessible, cost-effective, and precise. These drugs effectively target pathogens and cancer cells and even regulate metabolic pathways by focusing on specific intermediates. Monoclonal antibodies play a key role in mitigating a rise in occupation-related cancers, neurodegenerative disorders, and multidrug-resistant organisms. Here, we review the origins, mechanisms, and applications of this important drug class and explore future avenues for research.

Publisher

MDPI AG

Subject

General Medicine

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