Exploring the In Vitro Protective Effects of Green-Lipped Mussel (GLM) Oil Extract against Biomarkers of Glucose Metabolism and Inflammation in Chondrocyte Cells-Reference-Cited by-同舟云学术

Exploring the In Vitro Protective Effects of Green-Lipped Mussel (GLM) Oil Extract against Biomarkers of Glucose Metabolism and Inflammation in Chondrocyte Cells

Published:2023-12-19 Issue:1 Volume:4 Page:1-22
ISSN:1661-3821
Container-title:Nutraceuticals
language:en
Short-container-title:Nutraceuticals

Author:

Lessa Roberta Cardim¹,Ebrahimi Belgheis²,Guan Xiao³,Li Yan¹^ORCID,Lu Jun²³⁴^ORCID

Affiliation:

1. School of Science, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland 1142, New Zealand

2. Auckland Bioengineering Institute, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand

3. School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China

4. Department of Food and Agriculture Technology, Yangtze Delta Region Institute of Tsinghua University, Jiaxing 314006, China

Abstract

Chondrocyte behavior is critical in osteoarthritis (OA) progression and cartilage deterioration. Recent studies have shown that green-lipped mussel (GLM) oil extracts obtained through solvent extraction can regulate cytokine secretion in cell lines, potentially reducing inflammation and immune cell activation. This study investigates the effects of these extracts on human chondrocyte cell lines to understand their impact on osteoarthritis development. Chondrocyte cultures exposed to osteoarthritis-related inflammatory factors were treated with various concentrations of GLM oil. The results revealed that mussel oils, particularly a commercial mussel powder extract (SOLV.COM), enhance glucose uptake and protect chondrocyte cells. SOLV.COM effectively manages the release of inflammatory markers like interleukin-6 (IL-6) and matrix metalloproteinases-3 (MMP-3), showing increased deoxyglucose uptake. This study highlights the significant influence of extract choice on managing interleukin-6 (IL-6) secretion and cellular activation pathways, demonstrating the potential of SOLV.COM in managing osteoarthritis by controlling reactive oxygen production, regulating glucose metabolism, and inflammatory markers.

Funder

New Zealand National Science Challenge

High Value Nutrition Fund

China Ministry of Science and Technology 2023 National Foreign Experts Program

Publisher

MDPI AG

Link

https://www.mdpi.com/1661-3821/4/1/1/pdf

Reference83 articles.

1. Osteoarthritis: Pathogenic signaling pathways and therapeutic targets;Yao;Signal Transduct. Target. Ther.,2023

2. Fontanella, C.G., Belluzzi, E., Pozzuoli, A., Scioni, M., Olivotto, E., Reale, D., Ruggieri, P., De Caro, R., Ramonda, R., and Carniel, E.L. (2022). Exploring Anatomo-Morphometric Characteristics of Infrapatellar, Suprapatellar Fat Pad, and Knee Ligaments in Osteoarthritis Compared to Post-Traumatic Lesions. Biomedicines, 10.

3. He, Y., Li, Z., Alexander, P.G., Ocasio-Nieves, B.D., Yocum, L., Lin, H., and Tuan, R.S. (2020). Pathogenesis of osteoarthritis: Risk factors, regulatory pathways in chondrocytes, and experimental models. Biology, 9.

4. Ege, F. (2021). Rheum. Arthritis, IntechOpen.

5. Osteoarthritis pathogenesis–a complex process that involves the entire joint;Man;J. Med. Life,2014