Fomentariol, a Fomes fomentarius Compound, Exhibits Anti-Diabetic Effects in Fungal Material: An In Vitro Analysis-Reference-Cited by-同舟云学术

Fomentariol, a Fomes fomentarius Compound, Exhibits Anti-Diabetic Effects in Fungal Material: An In Vitro Analysis

Published:2024-05-21 Issue:2 Volume:4 Page:273-282
ISSN:1661-3821
Container-title:Nutraceuticals
language:en
Short-container-title:Nutraceuticals

Author:

Ravnikar Matjaž¹^ORCID,Štrukelj Borut¹,Otašević Biljana²^ORCID,Sirše Mateja³^ORCID

Affiliation:

1. Faculty of Pharmacy, University of Ljubljana, 1000 Ljubljana, Slovenia

2. Faculty of Pharmacy, University of Belgrade, 1221 Belgrade, Serbia

3. Alma Mater Europaea-ECM, 2000 Maribor, Slovenia

Abstract

The present study screened various fungal species for inhibitors of alpha-glucosidase, alpha-amylase, and DPP-4, enzymes that are crucial in carbohydrate metabolism. Ethanolic extracts exhibited superior inhibitory activity compared to water extracts, suggesting their potential as sources of anti-diabetic agents. Further fractionation revealed fomentariol from Fomes fomentarius as a potent inhibitor of alpha-glucosidase and DPP-4, with higher activity against alpha-glucosidase than acarbose. Fomentariol presents a novel avenue for diabetes management, demonstrating the simultaneous inhibition of key enzymes in glucose metabolism. However, comprehensive clinical studies are needed to evaluate its safety and efficacy in humans.

Funder

Ministry of Science, Technological Development and Innovation of the Republic of Serbia through Grant Agreement with the University of Belgrade–Faculty of Pharmacy

Publisher

MDPI AG

Link

https://www.mdpi.com/1661-3821/4/2/17/pdf

Reference38 articles.

1. (2023, October 01). International Diabetes Federation IDF Diabetes Atlas Fifth Edition 2021 [Internet]. Available online: https://diabetesatlas.org/atlas/tenth-edition/.

2. Barriers to Achieving Glycemic Targets: Who Omits Insulin and Why?;Weinger;Diabetes Care,2010

3. Distance to Glycemic Goal at the Time of Treatment Intensification in Patients with Type 2 Diabetes Mellitus Failing Metformin Monotherapy in the United States;Fernandes;Curr. Med. Res. Opin.,2020

4. Feingold, K.R. (2023, October 01). Oral and Injectable (Non-Insulin) Pharmacological Agents for Type 2 Diabetes, Available online: https://www.ncbi.nlm.nih.gov/books/NBK279141/.

5. Glycemic Control for Type 2 Diabetes Mellitus Patients: A Systematic Review;AlDuwayhis;Cureus,2022

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Antibacterial Efficacy and Characterization of Silver Nanoparticles Synthesized via Methanolic Extract of Fomes fomentarius L. Fr.;Molecules;2024-08-22