Infertility Treatment and Hypertension in Pregnancy: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study-Reference-Cited by-同舟云学术

Infertility Treatment and Hypertension in Pregnancy: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

Published:2023-04-18 Issue:2 Volume:4 Page:89-99
ISSN:2673-3897
Container-title:Reproductive Medicine
language:en
Short-container-title:Reprod. Med.

Author:

Ishikuro Mami¹²,Obara Taku¹²³^ORCID,Murakami Keiko¹²,Ueno Fumihiko¹²,Noda Aoi¹²³,Onuma Tomomi¹²,Matsuzaki Fumiko¹²^ORCID,Kikuya Masahiro¹⁴,Watanabe Zen²³,Shiga Naomi²³,Tachibana Masahito²,Iwama Noriyuki¹²³,Hamada Hirotaka²³,Saito Masatoshi²³,Sugawara Junichi¹²³⁵,Metoki Hirohito¹⁶,Yaegashi Nobuo¹²³,Kuriyama Shinichi¹²⁷

Affiliation:

1. Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8573, Japan

2. Graduate School of Medicine, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan

3. Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan

4. School of Medicine, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan

5. Suzuki Memorial Hospital, 3-5-5, Satonomori, Iwanuma 989-2481, Japan

6. Faculty of Medicine, Tohoku Medical and Pharmaceutical University, 1-15-1, Fukumuro, Miyagino-ku, Sendai 983-8536, Japan

7. International Research Institute of Disaster Science, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8573, Japan

Abstract

Infertility treatment is a possible factor in hypertensive disorders of pregnancy (HDP). Identifying the characteristics of pregnant women who have undergone infertility treatment and have a potential risk for HDP is valuable for its prevention and treatment. Using data from 12,456 pregnant Japanese women from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study, the association between infertility treatment and HDP was analyzed. A multiple logistic regression model showed an association between infertility treatment and HDP (odds ratio, 1.34; 95% confidence interval, 1.05–1.72). In vitro fertilization/intracytoplasmic sperm injection were also associated with HDP. Moreover, these associations were observed even among women who were not overweight and did not smoke. The application of infertility treatment should be carefully considered, even among women with low modifiable risk factors.

Funder

Japan Agency for Medical Research and Development

Publisher

MDPI AG

Subject

General Earth and Planetary Sciences,General Environmental Science

Link

https://www.mdpi.com/2673-3897/4/2/10/pdf

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