Engineered Vasculature for Cancer Research and Regenerative Medicine

Author:

Nguyen Huu Tuan1,Peirsman Arne12ORCID,Tirpakova Zuzana13,Mandal Kalpana1,Vanlauwe Florian2,Maity Surjendu1ORCID,Kawakita Satoru1,Khorsandi Danial1,Herculano Rondinelli14,Umemura Christian1,Yilgor Can1ORCID,Bell Remy1ORCID,Hanson Adrian1,Li Shaopei1,Nanda Himansu Sekhar15,Zhu Yangzhi1,Najafabadi Alireza Hassani1,Jucaud Vadim1ORCID,Barros Natan1,Dokmeci Mehmet Remzi1,Khademhosseini Ali1ORCID

Affiliation:

1. Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90064, USA

2. Plastic, Reconstructive and Aesthetic Surgery, Ghent University Hospital, 9000 Ghent, Belgium

3. Department of Biology and Physiology, University of Veterinary Medicine and Pharmacy in Kosice, Komenskeho 73, 04181 Kosice, Slovakia

4. Bioengineering & Biomaterials Group, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara 14800-903, SP, Brazil

5. Biomedical Engineering and Technology Laboratory, PDPM—Indian Institute of Information Technology Design Manufacturing, Jabalpur 482005, Madhya Pradesh, India

Abstract

Engineered human tissues created by three-dimensional cell culture of human cells in a hydrogel are becoming emerging model systems for cancer drug discovery and regenerative medicine. Complex functional engineered tissues can also assist in the regeneration, repair, or replacement of human tissues. However, one of the main hurdles for tissue engineering, three-dimensional cell culture, and regenerative medicine is the capability of delivering nutrients and oxygen to cells through the vasculatures. Several studies have investigated different strategies to create a functional vascular system in engineered tissues and organ-on-a-chips. Engineered vasculatures have been used for the studies of angiogenesis, vasculogenesis, as well as drug and cell transports across the endothelium. Moreover, vascular engineering allows the creation of large functional vascular conduits for regenerative medicine purposes. However, there are still many challenges in the creation of vascularized tissue constructs and their biological applications. This review will summarize the latest efforts to create vasculatures and vascularized tissues for cancer research and regenerative medicine.

Funder

National Institutes of Health

fonds Wetenschappelijk Onderzoek

fonds voor Hartchirurgie

Publisher

MDPI AG

Subject

Electrical and Electronic Engineering,Mechanical Engineering,Control and Systems Engineering

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