Pharmacist-Led Interventions for Medication Adherence in Patients with Chronic Kidney Disease: A Scoping Review

Author:

Calleja Luke1,Glass Beverley D.1ORCID,Cairns Alice23,Taylor Selina13ORCID

Affiliation:

1. Pharmacy, College of Medicine and Dentistry, James Cook University, Townsville 4811, Australia

2. Australian Institute of Tropical Health and Medicine, James Cook University, Cairns 4870, Australia

3. Murtupuni Mount Isa Centre for Rural and Remote Health, Mount Isa 4825, Australia

Abstract

Background: Patients with chronic kidney disease (CKD) are routinely prescribed complex medication regimes. Medication reconciliation, medicine reviews, patient counselling and disease state and medication education are all key pharmacist-led interventions, which can improve medication adherence in patients with CKD. Aim: To characterize peer reviewed literature on the role of pharmacists in supporting medication adherence of patients with chronic kidney disease and highlight the impact they might have in the health outcomes for patients. Method: This review was performed in accordance with the Scoping Review Framework outlined in the Joanna Briggs Institute Reviewer’s Guide. Four electronic databases were searched (Medline (Ovid), Emcare, Scopus and Web of Science) for all relevant literature published up until November 2022. A total of 32 studies were reviewed against an exclusion and inclusion criteria, with findings from each study categorized into barriers, interventions, perceptions, financial implications and outcomes. Results: Eight eligible studies were identified, where pharmacists’ interventions including medication reconciliation, medicine reviews, patient counselling and disease state and medication education, were all reported to have a positive effect on medication adherence. Although pharmacy services in chronic kidney disease were acceptable to patients and pharmacists, these services were under-utilized and limited by logistical constraints, including staffing shortages and time limitations. Patient education supplemented with education tools describing disease states and medications was reported to increase patient adherence to medication regimes. Conclusions: Pharmacist-led interventions play an integral role in improving medication adherence in patients with chronic kidney disease, with their inclusion in renal care settings having the potential to improve outcomes for patients.

Publisher

MDPI AG

Subject

Microbiology (medical),Immunology,Immunology and Allergy

Reference30 articles.

1. Kidney Health Australia (2020). Chronic Kidney Disease (CKD) Management in Primary Care, Kidney Health Australia.

2. Finkel, K.W., Perazella, M.A., and Cohen, E.P. (2020). Onco-Nephrology, Elsevier. [1st ed.].

3. Australian Institute of Health and Welfare—Department of Health (2014). Cardiovascular Disease, Diabetes and Chronic Kidney Disease: Australian Facts: Morbidity—Hospital Care 2014.

4. Paneerselvam, G.S., Aftab, R., Sirisinghe, R.G., Mei Lai, P.S., and Lim, S.K. (2022). Study protocol: Effectiveness of patient centered pharmacist care in improving medication adherence, clinical parameters and quality of life among hemodialysis patients. PloS ONE, 17.

5. A new taxonomy for describing and defining adherence to medications;Vrijens;Br. J. Clin. Pharmacol.,2012

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