Computational Analysis of Upscaled Fibrotic Liver Multi-Lobule Flows and Metabolism-Reference-Cited by-同舟云学术

Computational Analysis of Upscaled Fibrotic Liver Multi-Lobule Flows and Metabolism

Published:2024-08-23 Issue:9 Volume:12 Page:1789
ISSN:2227-9717
Container-title:Processes
language:en
Short-container-title:Processes

Author:

Coombe Dennis¹,Wallace Cooper²,Rezania Vahid²^ORCID,Tuszynski Jack A.³⁴⁵^ORCID

Affiliation:

1. Computer Modeling Group Inc., Calgary, AB T2L 2M1, Canada

2. Physical Sciences Department, MacEwan University, Edmonton, AB T5J 4S2, Canada

3. Department of Physics, University of Alberta, Edmonton, AB T6G 2E1, Canada

4. DIMEAS, Politecnico di Torino, 10129 Turin, Italy

5. Silesian University of Technology, 44-100 Gliwice, Poland

Abstract

The modeling of fibrotic effects on fluid flow and metabolism in the liver can be computationally challenging. This paper combines innovative concepts based on fundamental physics to address such issues at the level of the liver functional unit, the lobule, and upscales and extends this to a multi-lobule tissue scale analysis. Fibrosis effects on fluid flow and metabolism are introduced using percolation theory and its consequences are explored for single lobule and multi-lobule patterns, without and with distortion.

Publisher

MDPI AG

Link

https://www.mdpi.com/2227-9717/12/9/1789/pdf

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