Affiliation:
1. Formerly at the Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80521, USA
Abstract
In viral disease research, few diseases can compete with yellow fever for the volume of literature, historical significance, richness of the topics and the amount of strong interest among both scientists and laypersons. While the major foci of viral disease research shifted to other more pressing new diseases in recent decades, many critically important basic tasks still remain unfinished for yellow fever. Some of the examples include the mechanisms of transmission, the process leading to outbreak occurrence, environmental factors, dispersal, and viral persistence in nature. In this review, these subjects are analyzed in depth, based on information not only in old but in modern literatures, to fill in blanks and to update the current understanding on these topics. As a result, many valuable facts, ideas, and other types of information that complement the present knowledge were discovered. Very serious questions about the validity of the arbovirus concept and some research practices were also identified. The characteristics of YFV and its pattern of transmission that make this virus unique among viruses transmitted by Ae. aegypti were also explored. Another emphasis was identification of research questions. The discovery of a few historical surprises was an unexpected benefit.
Subject
Virology,Infectious Diseases
Reference303 articles.
1. WHO (1967). WHO Technical Report Series, WHO.
2. Anticontagionism between 1821 and 1867. The Fielding H. Garrison Lecture;Ackerknecht;Int. J. Epidemiol.,2009
3. Yellow fever in eighteenth century America;Blake;Bull. N. Y. Acad. Med.,1968
4. John Crawford and his contribution to the doctrine of contagium vivum;Doetsch;Bacteriol. Rev.,1964
5. Edward, J. (1811). A Lecture, Introductory to a Course of Lectures in the Cause, Seat and Cure of Diseases, Coale.