Affiliation:
1. Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, 50-551 Wroclaw, Poland
2. University Clinical Hospital, Wroclaw Medical University, 50-551 Wroclaw, Poland
Abstract
Kidney graft failure is not a homogenous disease and the Banff classification distinguishes several types of graft rejection. The maintenance of a transplant and the treatment of its failure require specific medications and differ due to the underlying molecular mechanism. As a consequence, patients suffering from different rejection types will experience distinct side-effects upon therapy. The review is focused on comparing treatment regimens as well as presenting the latest insights into innovative therapeutic approaches in patients with an ongoing active ABMR, chronic active ABMR, chronic ABMR, acute TCMR, chronic active TCMR, borderline and mixed rejection. Furthermore, the profile of cardiovascular adverse effects in relation to the applied therapy was subjected to scrutiny. Lastly, a detailed assessment and comparison of different approaches were conducted in order to identify those that are the most and least detrimental for patients suffering from kidney graft failure.
Funder
Wroclaw Medical University funds
Subject
Paleontology,Space and Planetary Science,General Biochemistry, Genetics and Molecular Biology,Ecology, Evolution, Behavior and Systematics
Reference125 articles.
1. Moein, M., Vlassis, I., Kim, L., Hanlon, M., and Saidi, R. (2023). Early readmissions post kidney transplantation: Lessons learned. Actas Urol. Esp.
2. Long-Term Kidney Transplant Outcomes: Role of Prolonged-Release Tacrolimus;Banas;Transplant. Proc.,2020
3. Protection against tacrolimus-induced cardiotoxicity in rats by olmesartan and aliskiren;Imam;Toxicol. Mech. Methods,2014
4. Incidence and Predictors of Myocardial Infarction after Kidney Transplantation;Lentine;J. Am. Soc. Nephrol.,2005
5. A 2018 Reference Guide to the Banff Classification of Renal Allograft Pathology;Roufosse;Transplantation,2018
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献