Pediatric Hemangiomas in the Female Genital Tract: A Literature Review

Author:

Merlino Lucia12ORCID,Volpicelli Agnese Immacolata2,Anglana Franco3,D’Ovidio Giulia2ORCID,Dominoni Mattia45ORCID,Pasquali Marianna Francesca45ORCID,Gardella Barbara45ORCID,Inghirami Paolo3,Lippa Pietro3,Senatori Roberto3

Affiliation:

1. Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 00161 Rome, Italy

2. Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00161 Rome, Italy

3. Vulvar Pathology Study Center, 00161 Roma, Italy

4. Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy

5. Department of Obstetrics and Gynecology, IRCCS Foundation Policlinico San Matteo, 27100 Pavia, Italy

Abstract

Background: Hemangiomas are aberrant proliferations of blood vessels and the most frequent benign pediatric soft tissue tumors. Although they are common, genital localization is rare. This study aimed to assist doctors in the diagnosis, management, and treatment of pediatric vulvovaginal hemangiomas by conducting a review of the literature. Methods: We conducted a literature review including papers published between August 2009 and May 2023. Results: While most hemangiomas are usually indolent and resolve with time, in some cases, especially cervicovaginal and uterine ones, they might present with severe symptoms like heavy bleeding and need further instrumental investigation for diagnosis, like CT or MRI. As for the treatment, many options are available, with medical therapy or expectant management being the first choice. Conclusions: Vulvovaginal pediatric hemangiomas are rare and require more research on how to detect and manage these lesions, especially the symptomatic and the psychologically impacting ones. For the time being, treatment should be personalized based on the patient’s situation and clinician’s expertise.

Publisher

MDPI AG

Reference28 articles.

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4. Infantile hemangioma. Part 1: Epidemiology, pathogenesis, clinical presentation and assessment;Bandera;J. Am. Acad. Dermatol.,2021

5. Venous malformations of the female lower genital tract;Wang;Eur. J. Obstet. Gynecol. Reprod. Biol.,2009

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