Surgical Resection and Immediate Reconstruction with a Bilayer Wound Collagen Matrix of a Rare Oral Angiosarcoma: A Case Report

Author:

Iacomino Enzo1,Fratini Chiara2ORCID,Sollima Laura3,Eibenstein Alberto4ORCID,Barbato Christian5ORCID,de Vincentiis Marco2,Minni Antonio26,Zoccali Federica2ORCID

Affiliation:

1. Department of Life, Health, and Environmental Sciences, Università degli Studi di L’Aquila, 67100 L’Aquila, Italy

2. Department of Sense Organs, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy

3. Anatomy and Pathological Histology Division, ASL 1 Avezzano-Sulmona-L’Aquila, San Salvatore Hospital, 67100 L’Aquila, Italy

4. Department of Applied Clinical and Biotechnological Sciences, University of Aquila, 67100 L’Aquila, Italy

5. Institute of Biochemistry and Cell Biology (IBBC-CNR), Department of Sense Organs, Sapienza University Rome, Policlinico Umberto I, 00161 Roma, Italy

6. Division of Otolaryngology-Head and Neck Surgery, ASL Rieti-Sapienza University, Ospedale San Camillo de Lellis, 02100 Rieti, Italy

Abstract

Angiosarcomas are malignant vascular tumors that commonly occur on the skin of the head and neck, breast, or scalp. Oral angiosarcoma is a rare tumor (0.0077% of all cancers in Europe), and regarding this atypical localization, no formal treatment trials have been conducted yet. We present a case of a 58-year-old female patient with a diagnosis of oral angiosarcoma. After tumor excision was performed by transoral surgical approach, immediate reconstruction of the intraoral surgical defects was made using Integra® bilayer wound collagen matrix. A skin regeneration technique has previously been reported to provide good healing for defects of buccal resection, preventing postoperative cicatricial fibrosis.

Publisher

MDPI AG

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