Abstract
To investigate developmental changes in immunity and different responses to weaning stress of piglets from different breeds during suckling and weaning periods, a total of 30 litters of Taoyuan black (TB) piglets, Xiangcun black (XB) piglets, and Duroc (DR) piglets (ten litters per breed) were selected at 1, 10, 21, and 24 days of age, respectively. The results showed that the liver index of TB piglets was higher at 10 days of age than that of the other days of age and breeds. Regardless of the days of age, TB and XB piglets had a higher plasma IgA level and lower ileal IgM level than in the DR piglets, and XB piglets had a lower plasma IgG level than the other breeds. TB and XB piglets had a higher IL-6 level and lower IL-17 level in plasma at 24 days of age than DR piglets, regardless of the days of age. The ileal levels of IL-2, IL-10, IFN-γ, and TNF-α were lower in the TB and XB piglets at 24 days of age than in the DR piglets. The ileal expression levels of IRAK1, CD14, MyD88, and NF-κB were down-regulated in the TB and XB piglets at 24 days of age compared to those in the DR piglets. These findings suggest that there were differences in the development of immune function among different pig breeds. Moreover, TB and XB piglets presented stronger resistance to weaning stress than the DR piglets, which may be related to the immune regulation mediated by the MyD88/NF-κB signaling pathway.
Funder
The Key Project of Regional Innovation and Development Joint Fund of National Natural Science Foundation of China
Youth Foundation of Guangxi Natural Science Foundation
Open Foundation of the Key Laboratory of Agro-Ecological Processes in Subtropical Region, Chinese Academy of Sciences
Special Funds for Construction of Innovative Provinces in Hunan Province
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference41 articles.
1. Maintenance of gut barrier integrity after injury: Trust your gut microRNAs;Morris;J. Leukoc. Biol.,2021
2. Development of gut immunoglobulin a production in piglet in response to innate and environmental factors;Levast;Dev. Comp. Immunol.,2014
3. Bæk, O., Skadborg, K., Muk, T., Amdi, C., Heegaard, P.M.H., Thymann, T., and Nguyen, D.N. (2021). Infant formula based on milk fat affects immune development in both normal birthweight and fetal growth restricted neonatal piglets. Nutrients, 13.
4. The pig as a model of developmental immunology;Sowa;Hum. Exp. Toxicol.,2002
5. Nutritional management of gut health in pigs around weaning;Bosi;Proc. Nutr. Soc.,2007
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