Deregulated Transcriptome as a Platform for Adrenal Huntington’s Disease-Related Pathology

Author:

Olechnowicz Anna12ORCID,Blatkiewicz Małgorzata1ORCID,Jopek Karol1ORCID,Isalan Mark34,Mielcarek Michal34ORCID,Rucinski Marcin1ORCID

Affiliation:

1. Department of Histology and Embryology, Poznan University of Medical Sciences, 61-701 Poznan, Poland

2. Doctoral School, Poznan University of Medical Sciences, 60-812 Poznan, Poland

3. Department of Life Sciences, Imperial College London, Exhibition Road, London SW7 2AZ, UK

4. Imperial College Centre for Synthetic Biology, Imperial College London, London SW7 2AZ, UK

Abstract

Huntington’s disease (HD) is a neurodegenerative disorder that affects mainly the central nervous system (CNS) by inducing progressive deterioration in both its structure and function. In recent years, there has been growing interest in the impact of HD on peripheral tissue function. Herein, we used the R6/2 mouse model of HD to investigate the influence of the disease on adrenal gland functioning. A transcriptomic analysis conducted using a well-established quantitative method, an Affymetrix array, revealed changes in gene expression in the R6/2 model compared to genetic background controls. For the first time, we identified disruptions in cholesterol and sterol metabolism, blood coagulation, and xenobiotic metabolism in HD adrenal glands. This study showed that the disrupted expression of these genes may contribute to the underlying mechanisms of Huntington’s disease. Our findings may contribute to developing a better understanding of Huntington’s disease progression and aid in the development of novel diagnostic or therapeutic approaches.

Funder

National Science Centre in Poland

Publisher

MDPI AG

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