Pathophysiology, Histopathology, and Differential Diagnostics of Basal Cell Carcinoma and Cutaneous Squamous Cell Carcinoma—An Update from the Pathologist’s Point of View-Reference-Cited by-同舟云学术

Pathophysiology, Histopathology, and Differential Diagnostics of Basal Cell Carcinoma and Cutaneous Squamous Cell Carcinoma—An Update from the Pathologist’s Point of View

Published:2024-02-13 Issue:4 Volume:25 Page:2220
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Cocuz Iuliu Gabriel¹²^ORCID,Popelea Maria Cătălina²,Niculescu Raluca¹²,Manea Andrei³^ORCID,Sabău Adrian-Horațiu¹²,Tinca Andreea-Cătălina¹²^ORCID,Szoke Andreea Raluca¹²^ORCID,Budin Corina Eugenia¹⁴^ORCID,Stoian Adina¹⁵^ORCID,Morariu Silviu Horia⁶⁷,Cotoi Titiana Cornelia⁸⁹,Cocuz Maria-Elena¹⁰¹¹^ORCID,Cotoi Ovidiu Simion¹²

Affiliation:

1. Pathophysiology Department, “George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, 540142 Targu Mures, Romania

2. Pathology Department, Mures Clinical County Hospital, 540011 Targu Mures, Romania

3. Faculty of Medicine, “George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, 540142 Targu Mures, Romania

4. Pneumology Department, Mures Clinical County Hospital, 540011 Targu Mures, Romania

5. Neurology I Clinic, Targu Mures Emergency County Hospital, 540136 Targu Mures, Romania

6. Dermatology Department, “George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, 540142 Targu Mures, Romania

7. Dermatology Department, Mures Clinical County Hospital, 540011 Targu Mures, Romania

8. Pharmaceutical Technique Department, “George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, 540142 Targu Mures, Romania

9. Pharmacy No. 2, Mures Clinical County Hospital, 540011 Targu Mures, Romania

10. Fundamental Prophylactic and Clinical Disciplines Department, Faculty of Medicine, Transilvania University of Brasov, 500003 Brașov, Romania

11. Clinical Pneumology and Infectious Diseases Hospital of Brasov, 500174 Brasov, Romania

Abstract

Basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC) are the most frequently occurring non-melanocytic skin cancers. The objective of our study is to present the pathophysiology of BCC and cSCC and its direct relationship with the histopathological diagnostics and the differential diagnostics of these types of cancer, based on the morphological characteristics, immunohistochemical profile, and genetic alterations. The qualitative study was based on emphasizing the morphological characteristics and immunohistochemistry profiles of BCC and cSCC and the differential diagnostics based on the tissue samples from the Clinical Pathology Department of Mures Clinical County Hospital between 2020 and 2022. We analyzed the histopathological appearances and immunohistochemical profiles of BCC and cSCC in comparison with those of Bowen disease, keratoacanthoma, hyperkeratotic squamous papilloma, metatypical carcinoma, pilomatricoma, trichoblastoma, Merkel cell carcinoma, pleomorphic dermal sarcoma (PDS), and melanoma. Our study showed the importance of the correct histopathological diagnosis, which has a direct impact on the appropriate treatment and outcome for each patient. The study highlighted the histopathological and morphological characteristics of NMSCs and the precursor lesions in HE and the immunohistochemical profile for lesions that may make the differential diagnosis difficult to establish.

Funder

“George Emil Palade” University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Romania

Publisher

MDPI AG

Link

https://www.mdpi.com/1422-0067/25/4/2220/pdf

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