Improved Graft Function following Desensitization of Anti-AT1R and Autoantibodies in a Heart Transplant Recipient Negative for Donor-Specific Antibodies with Antibody-Mediated Rejection: A Case Report-Reference-Cited by-同舟云学术

Improved Graft Function following Desensitization of Anti-AT1R and Autoantibodies in a Heart Transplant Recipient Negative for Donor-Specific Antibodies with Antibody-Mediated Rejection: A Case Report

Published:2024-02-12 Issue:4 Volume:25 Page:2218
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Jung Regina¹^ORCID,Ly Kevin²,Taniguchi Michiko³⁴,Arriola Aileen Grace³⁴,Gravante Christopher³,Shinn Derek³,Mathew Leena³,Hamad Eman⁵^ORCID,Geier Steven³⁴,Liacini Abdelhamid³⁴

Affiliation:

1. Department of Pharmacy, Lahey Hospital and Medical Center, Burlington, MA 01805, USA

2. Department of Pharmacy, Temple University Hospital, Philadelphia, PA 19140, USA

3. Immunogenetics Laboratory, Temple University Hospital, Philadelphia, PA 19140, USA

4. Department of Pathology and Laboratory Medicine, Lewis Katz School of Medicine, Philadelphia, PA 19140, USA

5. Heart and Vascular Institute, Section of Cardiology, Lewis Katz School of Medicine, Philadelphia, PA 19140, USA

Abstract

HLA donor-specific antibodies (DSAs) pre and post transplant increase the risk of antibody-mediated rejection (AMR) and lead to poor graft survival. Increasing data exist to support the involvement of non-HLA antibodies in triggering an immunological response. The development of non-HLA antibodies specific for AT1R is associated with poor clinical outcomes in orthotopic heart transplant recipients. This case presents an investigation of non-HLA antibodies in a 56-year-old female heart transplant recipient diagnosed with AMR in the absence of DSAs.

Publisher

MDPI AG

Link

https://www.mdpi.com/1422-0067/25/4/2218/pdf

Reference22 articles.

1. The importance of non-HLA antibodies in transplantation;Zhang;Nat. Rev. Nephrol.,2016

2. Angiotensin II Type 1 Receptor Antibody-mediated Rejection Following Orthotopic Heart Transplant: A Single-center Experience;Moreno;Transplantation,2022

3. The management of antibodies in heart transplantation: An ISHLT consensus document;Kobashigawa;J. Heart Lung Transpl.,2018

4. De novo donor HLA-specific antibodies after heart transplantation are an independent predictor of poor patient survival;Smith;Am. J. Transpl.,2011

5. Donor-specific anti-HLA antibodies with antibody-mediated rejection and long-term outcomes following heart transplantation;Clerkin;J. Heart Lung Transpl.,2017