Affiliation:
1. Department of Biology, University of Naples Federico II, 80126 Naples, Italy
2. Department of Conservation of Marine Animals and Public Engagement, Anton Dohrn Zoological Station, 80122 Naples, Italy
3. Department of Science and Technology, University of Naples Parthenope, 80133 Naples, Italy
Abstract
Psychotropic drugs and benzodiazepines are nowadays among the primary substances of abuse. This results in a large and constant release into aquatic environments where they have potentially harmful effects on non-target organisms and, eventually, human health. In the last decades, evidence has been collected on the possible interference of benzodiazepines with reproductive processes, but data are few and incomplete. In this study, the possible negative influence of delorazepam on fertilization and embryo development has been tested in Paracentrotus lividus, a key model organism in studies of reproduction and embryonic development. Sperm, eggs, or fertilized eggs have been exposed to delorazepam at three concentrations: 1 μg/L (environmentally realistic), 5 μg/L, and 10 μg/L. Results indicate that delorazepam reduces the fertilizing capacity of male and female gametes and interferes with fertilization and embryo development. Exposure causes anatomical anomalies in plutei, accelerates/delays development, and alters the presence and distribution of glycoconjugates such as N-Acetyl-glucosamine, α-linked fucose, and α-linked mannose in both morulae and plutei. These results should attract attention to the reproductive fitness of aquatic species exposed to benzodiazepines and pave the way for further investigation of the effects they may exert on human fertility. The presence of benzodiazepines in the aquatic environment raises concerns about the reproductive well-being of aquatic species. Additionally, it prompts worries regarding potential impacts on human fertility due to the excessive use of anxiolytics.
Reference78 articles.
1. Dos Santos, C.R., Lebron, Y.A.R., Moreira, V.R., Koch, K., and Amaral, M.C.S. (2022). Biodegradability, environmental risk assessment and ecological footprint in wastewater technologies for pharmaceutically active compounds removal. Bioresour. Technol., 343.
2. Pharmaceutically active compounds in aqueous environment: A status, toxicity and insights of remediation;Majumder;Environ. Res.,2019
3. Occurrence, distribution and environmental risk of pharmaceutically active compounds (PhACs) in coastal and ocean waters from the Gulf of Cadiz (SW Spain);Sci. Total Environ.,2018
4. A review of pharmaceutical occurrence and pathways in the aquatic environment in the context of a changing climate and the COVID-19 pandemic;Lawler;Anal. Methods Adv. Methods Appl.,2021
5. Effect of the COVID-19 pandemic on the psychotropic drug consumption;Benistand;Front. Psychiatry,2022
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