Lung Inflammatory Phenotype in Mice Deficient in Fibulin-2 and ADAMTS-12

Author:

Mohamedi Yamina1,Fontanil Tania1ORCID,Vega José A.23ORCID,Cobo Teresa45,Cal Santiago1,Obaya Álvaro J.67

Affiliation:

1. Departamento de Bioquímica y Biología Molecular, Universidad de Oviedo, 33006 Oviedo, Spain

2. Departamento de Morfología y Biología Celular, Universidad de Oviedo, 33006 Oviedo, Spain

3. Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Providencia—Área Metropolinana, Santiago de Chile 7500912, Chile

4. Departamento de Cirugía y Especialidades Médico-Quirúrgicas, Universidad de Oviedo, 33006 Oviedo, Spain

5. Instituto Asturiano de Odontología (IAO), 33006 Oviedo, Spain

6. Departamento de Biología Funcional, Área de Fisiología, Universidad de Oviedo, 33006 Oviedo, Spain

7. Instituto Universitario de Oncología del Principado de Asturias (IUOPA), 33006 Oviedo, Spain

Abstract

Interaction between extracellular matrix (ECM) components plays an important role in the regulation of cellular behavior and hence in tissue function. Consequently, characterization of new interactions within ECM opens the possibility of studying not only the functional but also the pathological consequences derived from those interactions. We have previously described the interaction between fibulin2 and ADAMTS-12 in vitro and the effects of that interaction using cellular models of cancer. Now, we generate a mouse deficient in both ECM components and evaluate functional consequences of their absence using different cancer and inflammation murine models. The main findings indicate that mice deficient in both fibulin2 and ADAMTS12 markedly increase the development of lung tumors following intraperitoneal urethane injections. Moreover, inflammatory phenotype is exacerbated in the lung after LPS treatment as can be inferred from the accumulation of active immune cells in lung parenchyma. Overall, our results suggest that protective effects in cancer or inflammation shown by fibulin2 and ADAMTS12 as interactive partners in vitro are also shown in a more realistic in vivo context.

Funder

Ministerio Español de Ciencia, Innovación y Universidades

Instituto Asturiano de Odolontología, IAO

Publisher

MDPI AG

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