Abstract
Nowadays, leishmaniasis constitutes a public health issue in more than 88 countries, affecting mainly people from the tropics, subtropics, and the Mediterranean area. Every year, the prevalence of this infectious disease increases, with the appearance of 1.5–2 million new cases of cutaneous leishmaniasis and 500,000 cases of visceral leishmaniasis, endangering approximately 350 million people worldwide. Therefore, the absence of a vaccine or effective treatment makes the discovery and development of new antileishmanial therapies one of the focuses for the scientific community that, in association with WHO, hopes to eradicate this disease shortly. This paper is intended to highlight the relevance of nitrogen- and oxygen-containing tricyclic heterocycles, particularly acridine and xanthene derivatives, for the development of treatments against leishmaniasis. Thus, in this review, a thorough compilation of the most promising antileishmanial acridine and xanthene derivatives is performed from both natural and synthetic origins. Additionally, some structure–activity relationship studies are also depicted and discussed to provide insight into the optimal structural features responsible for these compounds’ antileishmanial activity.
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
Reference68 articles.
1. The Control of Leishmaniaseshttp://www.nature.com/doifinder/10.1038/nrmicro1766
2. Leishmaniasis: Magnitude of the Problemhttp://www.who.int/leishmaniasis/burden/magnitude/burden_magnitude/en/
3. Mechanisms of Immunopathogenesis in Cutaneous Leishmaniasis And Post Kala-azar Dermal Leishmaniasis (PKDL)
4. Leishmaniasis Fact Sheet No375http://www.who.int/mediacentre/factsheets/fs375/en/
5. Leishmaniasis: Clinical Forms of the Leishmaniaseshttp://www.who.int/leishmaniasis/clinical_forms_leishmaniases/en/index2.html
Cited by
12 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献